一种从限制性数据估计群体内部和群体之间核苷酸替换平均数量的简单方法。
A simple method for estimating average number of nucleotide substitutions within and between populations from restriction data.
作者信息
Nei M, Miller J C
机构信息
Center for Demographic and Population Genetics, University of Texas Health Science Center, Houston 77225.
出版信息
Genetics. 1990 Aug;125(4):873-9. doi: 10.1093/genetics/125.4.873.
Abstract
A simple method is proposed for estimating the average number of nucleotide substitutions per site within and between populations for the case where a large number of individuals are examined for many restriction enzymes. This method gives essentially the same results as those obtained by Nei and Li's method but saves a large amount of computer time. The variances of the quantities estimated can be obtained by the jackknife method, and these variances are very similar to those obtained by Nei and Jin's more sophisticated method. A similar method can also be applied to DNA sequence data.
摘要
本文提出了一种简单的方法，用于估计在对大量个体进行多种限制性内切酶检测的情况下，群体内部和群体之间每个位点的核苷酸替代平均数量。该方法得到的结果与内和李的方法基本相同，但节省了大量的计算机时间。估计量的方差可以通过刀切法获得，这些方差与内和金更复杂的方法得到的方差非常相似。类似的方法也可以应用于DNA序列数据。
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本文引用的文献
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Maximum likelihood estimation of the number of nucleotide substitutions from restriction sites data.基于限制性酶切位点数据的核苷酸替换数的最大似然估计。
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DNA polymorphism detectable by restriction endonucleases.可通过限制性核酸内切酶检测到的DNA多态性。
Genetics. 1981 Jan;97(1):145-63. doi: 10.1093/genetics/97.1.145.
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6
Variances of the average numbers of nucleotide substitutions within and between populations.群体内部和群体之间核苷酸替换平均数的方差。
Mol Biol Evol. 1989 May;6(3):290-300. doi: 10.1093/oxfordjournals.molbev.a040547.
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Inference of haplotypes from PCR-amplified samples of diploid populations.从二倍体群体的PCR扩增样本中推断单倍型。
Mol Biol Evol. 1990 Mar;7(2):111-22. doi: 10.1093/oxfordjournals.molbev.a040591.
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Mathematical model for studying genetic variation in terms of restriction endonucleases.基于限制性内切酶研究基因变异的数学模型。
Proc Natl Acad Sci U S A. 1979 Oct;76(10):5269-73. doi: 10.1073/pnas.76.10.5269.
9
A new estimate of sequence divergence of mitochondrial DNA using restriction endonuclease mappings.利用限制性内切酶图谱对线粒体DNA序列差异的新估计。
J Mol Evol. 1979 Nov;13(4):295-304. doi: 10.1007/BF01731370.
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