基于限制性酶切位点数据的核苷酸替换数的最大似然估计。
Maximum likelihood estimation of the number of nucleotide substitutions from restriction sites data.
作者信息
Nei M, Tajima F
出版信息
Genetics. 1983 Sep;105(1):207-17. doi: 10.1093/genetics/105.1.207.
Abstract
A simple method of the maximum likelihood estimation of the number of nucleotide substitutions is presented for the case where restriction sites data from many different restriction enzymes are available. An iteration method, based on nucleotide counting, is also developed. This method is simpler than the maximum likelihood method but gives the same estimate. A formula for computing the variance of a maximum likelihood estimate is also presented.
摘要
针对可获得多种不同限制酶的限制位点数据的情况，提出了一种估计核苷酸替换数目的简单最大似然估计方法。还开发了一种基于核苷酸计数的迭代方法。该方法比最大似然方法更简单，但给出相同的估计值。同时还给出了一个计算最大似然估计方差的公式。
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本文引用的文献
1
Estimation of average number of nucleotide substitutions when the rate of substitution varies with nucleotide.当替换率随核苷酸变化时核苷酸替换平均数量的估计
J Mol Evol. 1982;18(6):414-23. doi: 10.1007/BF01840889.
2
Estimation of phylogenetic relationships from DNA restriction patterns and selection of endonuclease cleavage sites.根据DNA限制性酶切图谱估计系统发育关系及选择核酸内切酶切割位点
Proc Natl Acad Sci U S A. 1982 Jun;79(11):3560-4. doi: 10.1073/pnas.79.11.3560.
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DNA polymorphism detectable by restriction endonucleases.可通过限制性核酸内切酶检测到的DNA多态性。
Genetics. 1981 Jan;97(1):145-63. doi: 10.1093/genetics/97.1.145.
4
An improved method for estimating sequence divergence between related DNAs from changes in restriction endonuclease cleavage sites.一种根据限制性内切酶切割位点变化来估算相关DNA序列差异的改进方法。
J Mol Evol. 1979 Dec;14(4):301-10. doi: 10.1007/BF01732497.
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A new estimate of sequence divergence of mitochondrial DNA using restriction endonuclease mappings.利用限制性内切酶图谱对线粒体DNA序列差异的新估计。
J Mol Evol. 1979 Nov;13(4):295-304. doi: 10.1007/BF01731370.
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