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基于限制性酶切位点数据的核苷酸替换数的最大似然估计。

Maximum likelihood estimation of the number of nucleotide substitutions from restriction sites data.

作者信息

Nei M, Tajima F

出版信息

Genetics. 1983 Sep;105(1):207-17. doi: 10.1093/genetics/105.1.207.

DOI:10.1093/genetics/105.1.207
PMID:6311668
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1202146/
Abstract

A simple method of the maximum likelihood estimation of the number of nucleotide substitutions is presented for the case where restriction sites data from many different restriction enzymes are available. An iteration method, based on nucleotide counting, is also developed. This method is simpler than the maximum likelihood method but gives the same estimate. A formula for computing the variance of a maximum likelihood estimate is also presented.

摘要

针对可获得多种不同限制酶的限制位点数据的情况，提出了一种估计核苷酸替换数目的简单最大似然估计方法。还开发了一种基于核苷酸计数的迭代方法。该方法比最大似然方法更简单，但给出相同的估计值。同时还给出了一个计算最大似然估计方差的公式。

相似文献

1
Maximum likelihood estimation of the number of nucleotide substitutions from restriction sites data.基于限制性酶切位点数据的核苷酸替换数的最大似然估计。
Genetics. 1983 Sep;105(1):207-17. doi: 10.1093/genetics/105.1.207.
2
Biases of the estimates of DNA divergence obtained by the restriction enzyme technique.通过限制酶技术获得的DNA分歧估计值的偏差。
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3
Nonrandom amino acid substitution and estimation of the number of nucleotide substitutions in evolution.进化过程中氨基酸的非随机替换及核苷酸替换数的估计
J Mol Evol. 1978 Oct 6;11(4):333-47. doi: 10.1007/BF01733841.
4
Estimation of average number of nucleotide substitutions when the rate of substitution varies with nucleotide.当替换率随核苷酸变化时核苷酸替换平均数量的估计
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5
A simulation study on Nei and Li's model for estimating DNA divergence from restriction enzyme maps.关于Nei和Li从限制性酶切图谱估计DNA分歧模型的模拟研究。
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6
A simple method for estimating average number of nucleotide substitutions within and between populations from restriction data.一种从限制性数据估计群体内部和群体之间核苷酸替换平均数量的简单方法。
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7
Optimal use of restriction enzymes in the analysis of human DNA polymorphism.限制酶在人类DNA多态性分析中的优化应用。
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本文引用的文献

1
Estimation of average number of nucleotide substitutions when the rate of substitution varies with nucleotide.当替换率随核苷酸变化时核苷酸替换平均数量的估计
J Mol Evol. 1982;18(6):414-23. doi: 10.1007/BF01840889.
2
Estimation of phylogenetic relationships from DNA restriction patterns and selection of endonuclease cleavage sites.根据DNA限制性酶切图谱估计系统发育关系及选择核酸内切酶切割位点
Proc Natl Acad Sci U S A. 1982 Jun;79(11):3560-4. doi: 10.1073/pnas.79.11.3560.
3
DNA polymorphism detectable by restriction endonucleases.可通过限制性核酸内切酶检测到的DNA多态性。
Genetics. 1981 Jan;97(1):145-63. doi: 10.1093/genetics/97.1.145.
4
An improved method for estimating sequence divergence between related DNAs from changes in restriction endonuclease cleavage sites.一种根据限制性内切酶切割位点变化来估算相关DNA序列差异的改进方法。
J Mol Evol. 1979 Dec;14(4):301-10. doi: 10.1007/BF01732497.
5
A new estimate of sequence divergence of mitochondrial DNA using restriction endonuclease mappings.利用限制性内切酶图谱对线粒体DNA序列差异的新估计。
J Mol Evol. 1979 Nov;13(4):295-304. doi: 10.1007/BF01731370.