基于限制性内切酶研究基因变异的数学模型。
Mathematical model for studying genetic variation in terms of restriction endonucleases.
作者信息
Nei M, Li W H
出版信息
Proc Natl Acad Sci U S A. 1979 Oct;76(10):5269-73. doi: 10.1073/pnas.76.10.5269.
Abstract
A mathematical model for the evolutionary change of restriction sites in mitochondrial DNA is developed. Formulas based on this model are presented for estimating the number of nucleotide substitutions between two populations or species. To express the degree of polymorphism in a population at the nucleotide level, a measure called "nucleotide diversity" is proposed.
摘要
建立了一个线粒体DNA中限制性酶切位点进化变化的数学模型。基于该模型给出了用于估计两个群体或物种间核苷酸替换数目的公式。为了在核苷酸水平上表达群体中的多态性程度，提出了一种称为“核苷酸多样性”的度量方法。
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