Friman G, Schiller H H, Schwartz M
Scand J Infect Dis. 1977;9(2):99-103. doi: 10.3109/inf.1977.9.issue-2.08.
14 subjects with influenza or echovirus infection, all suffering myalgia, and 9 subjects with mumps, in whom this symptom was lacking, were investigated with single fibre electromyography (EMG) in the acute phase and during convalescence to reveal a possible disturbance in neuromuscular transmission. In both groups about the same percentage of the potential pairs studied showed abnormal transmission characteristics in the acute phase. Two weeks after the acute infection, this percentage had decreased significantly in the group with myalgia, whilst in the non-myalgia group it was still at the same level. However, on both occasions of investigation and in both groups the percentages were substantially greater than those recorded in healthy individuals. This study demonstrates that acute febrile infections may adversely affect neuromuscular transmission in previously healthy human subjects. The effects observed might offer an explanation to the accentuated muscular weakness in association with infections in patients with an already low safety margion of neuromuscular transmission, e.g. in myasthenia gravis.
对14名患有流感或埃可病毒感染且均伴有肌痛的受试者，以及9名未出现该症状的腮腺炎患者，在急性期和恢复期进行了单纤维肌电图（EMG）检查，以揭示神经肌肉传递可能存在的紊乱。在急性期，两组中所研究的潜在肌纤维对出现异常传递特征的比例大致相同。急性感染两周后，伴有肌痛的组中该比例显著下降，而无肌痛组仍维持在相同水平。然而，在两次检查中，两组的该比例均大大高于健康个体的记录值。本研究表明，急性发热性感染可能对既往健康的人体受试者的神经肌肉传递产生不利影响。所观察到的这些影响可能为神经肌肉传递安全裕度本就较低的患者（如重症肌无力患者）在感染时出现的肌肉无力加重现象提供一种解释。
