Hauber H-P, Kirsten D
Medizinische Klinik, Forschungszentrum Borstel, Borstel.
Z Rheumatol. 2009 Oct;68(8):621-4, 626-9. doi: 10.1007/s00393-009-0479-6.
Vasculitis and connective tissue disease are often associated with interstitial lung disease. Involvement of lung parenchyma is found in small vessel vasculitis and mostly in ANCA-associated forms such as Wegener's granulomatosis. In addition to vasculitis and connective tissue disease, rheumatoid arthritis can lead to interstitial lung disease and lung fibrosis. Diagnostic tools include measurement of auto-antibodies, lung function test, chest X-rays and computed tomography of the thorax, as well as bronchoscopy with biopsy and bronchoalveolar lavage. The following article provides an overview of the clinical, histological and radiologic patterns of interstitial lung disease in vasculitis, rheumatoid arthritis and connective tissue disease. Treatment options will also be discussed.
血管炎和结缔组织病常与间质性肺疾病相关。肺实质受累见于小血管炎，且多见于抗中性粒细胞胞浆抗体（ANCA）相关的类型，如韦格纳肉芽肿。除血管炎和结缔组织病外，类风湿关节炎可导致间质性肺疾病和肺纤维化。诊断工具包括自身抗体检测、肺功能测试、胸部X线和胸部计算机断层扫描，以及支气管镜检查及活检和支气管肺泡灌洗。以下文章概述了血管炎、类风湿关节炎和结缔组织病中间质性肺疾病的临床、组织学和放射学表现。还将讨论治疗方案。
