Grill V, Gutniak M, Roovete A, Efendić S
J Clin Endocrinol Metab. 1984 Aug;59(2):293-7. doi: 10.1210/jcem-59-2-293.
The effect of oral glucose (1 g/kg BW) on levels of immunoreactive somatostatin (SLI) in peripheral venous plasma was investigated in young and older nondiabetic subjects (mean ages, 25.8 and 56.7 yr, respectively) as well as in subjects with decreased iv glucose tolerance (K value less than 1.0) and in diet-treated diabetic patients with fasting hyperglycemia (blood glucose, greater than 7.0 mmol/liter). SLI was assayed after extraction of plasma on silica glass beads. In control experiments (glucose omitted), SLI levels tended to decline. Ingestion of glucose was followed by a moderate (52% or less) increase in SLI levels in subjects with normal or decreased iv glucose tolerance. The stimulating effect was sustained for 90 or 120 min after glucose ingestion and the increase in plasma SLI was significant (P less than 0.05-0.02) whether in relation to prestimulatory values or control experiments. In contrast, in overtly diabetic patients, glucose ingestion was not followed by increased SLI levels. It is concluded that oral glucose stimulates SLI secretion in individuals of different ages and with varying degrees of glucose tolerance, but the response is impaired in type 2 diabetic patients with fasting hyperglycemia.
研究了口服葡萄糖（1克/千克体重）对年轻和老年非糖尿病受试者（平均年龄分别为25.8岁和56.7岁）、静脉葡萄糖耐量降低（K值小于1.0）的受试者以及饮食治疗的空腹血糖升高（血糖大于7.0毫摩尔/升）的糖尿病患者外周静脉血浆中免疫反应性生长抑素（SLI）水平的影响。在硅胶玻璃珠上提取血浆后测定SLI。在对照实验（省略葡萄糖）中，SLI水平有下降趋势。口服葡萄糖后，静脉葡萄糖耐量正常或降低的受试者的SLI水平适度升高（52%或更低）。葡萄糖摄入后，刺激作用持续90或120分钟，无论相对于刺激前值还是对照实验，血浆SLI的升高均具有显著性（P小于0.05 - 0.02）。相比之下，在显性糖尿病患者中，口服葡萄糖后SLI水平并未升高。得出的结论是，口服葡萄糖可刺激不同年龄和不同葡萄糖耐量程度个体的SLI分泌，但空腹血糖升高的2型糖尿病患者的反应受损。
