Jilin Provincial Academy of Chinese Medicine Sciences, Changchun 130021, China.
J Ethnopharmacol. 2009 Dec 10;126(3):487-91. doi: 10.1016/j.jep.2009.09.009. Epub 2009 Sep 15.
Saururus chinensis (Lour.) Baill (Saururaceae) has been used in Chinese folk medicine for treatment of various diseases, such as edema, jaundice, gonorrhea, antipyretic, diuretic, and antiinflammatory agents.
Our aim was to evaluate the hepatoprotective and antifibrotic effects of Saururus chinensis extract (SC-E) in carbon tetrachloride (CCl(4)) induced liver fibrosis rats.
The SC-E (70 mg/kg) was administrated via gavage once a day starting from the onset of CCl(4) treatment (14 weeks) for subsequent 8 weeks. Evaluated with liver index, serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), hyaluronic acid (HA), hepatic malondialdehyde (MDA) content, and superoxide dismutase (SOD) activity, total cholesterol (TC), triglyceride (TG), total lipoprotein (TP), albumin (ALB), hydroxyproline (HYP), total antioxidant capacity (T-AOC), laminin (LN), type III collagen terminal peptide (PC-IIINP), and type IV collagen (IV-C), as well as with histopathologic changes of liver.
SC-E effectively reduced the elevated levels of liver index, serum ALT, AST, HA, and hepatic MDA contents, enhance the reduced hepatic SOD activity in CCl(4)-treated rats. The histopathological analysis suggested that SC-E obviously alleviated the degree of liver fibrosis induced by CCl(4).
Those results suggest SC-E has protective and therapeutic effects on liver fibrosis induced by CCl(4).
中华石龙尾（Lour.）Baill（鸭跖草科）在中国民间医学中用于治疗各种疾病，如水肿，黄疸，淋病，解热，利尿和抗炎药。
我们的目的是评估中华石龙尾提取物（SC-E）在四氯化碳（CCl 4 ）诱导的肝纤维化大鼠中的保肝和抗纤维化作用。
SC-E（70mg/kg）通过灌胃给药，每天一次，从 CCl 4 治疗开始（14 周），随后 8 周。通过肝指数，血清丙氨酸氨基转移酶（ALT），天冬氨酸氨基转移酶（AST），透明质酸（HA），肝丙二醛（MDA）含量和超氧化物歧化酶（SOD）活性，总胆固醇（TC），甘油三酯（TG），总脂蛋白（TP），白蛋白（ALB），羟脯氨酸（HYP），总抗氧化能力（T-AOC），层粘连蛋白（LN），III 型胶原末端肽（PC-IIINP）和 IV 型胶原（IV-C）以及肝组织病理学变化进行评估。
SC-E 有效降低了 CCl 4 处理大鼠肝指数，血清 ALT，AST，HA 和肝 MDA 含量的升高，增强了肝 SOD 活性的降低。组织病理学分析表明，SC-E 明显减轻了 CCl 4 诱导的肝纤维化程度。
这些结果表明，SC-E 对 CCl 4 诱导的肝纤维化具有保护和治疗作用。
