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在噪音问题上并非一切都平静。

Not all quiet on the noise front.

作者信息

McCullagh Emma, Farlow Justin, Fuller Christopher, Girard Juliet, Lipinski-Kruszka Joanna, Lu Dan, Noriega Thomas, Rollins Geoffrey, Spitzer Russell, Todhunter Michael, El-Samad Hana

机构信息

TETRAD Graduate Program, University of California, San Francisco, California, USA.

出版信息

Nat Chem Biol. 2009 Oct;5(10):699-704. doi: 10.1038/nchembio.222.

DOI:10.1038/nchembio.222
PMID:19763097
Abstract

Phenotypic diversity exists even within isogenic populations of cells. Such nongenetic individuality may have wide implications for our understanding of many biological processes. The field of study concerned with the investigation of nongenetic individuality, also known as the 'biology of noise', is ripe with exciting scientific opportunities and challenges.

摘要

即使在同基因细胞群体中也存在表型多样性。这种非遗传个体性可能对我们理解许多生物学过程具有广泛影响。研究非遗传个体性的领域,也被称为“噪声生物学”,充满了令人兴奋的科学机遇和挑战。

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Determining the Limitations and Benefits of Noise in Gene Regulation and Signal Transduction through Single Cell, Microscopy-Based Analysis.通过基于显微镜的单细胞分析确定噪声在基因调控和信号转导中的局限性和益处。
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本文引用的文献

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Cancer stem cells and their niche.癌症干细胞及其微环境。
Cancer Sci. 2009 Jul;100(7):1166-72. doi: 10.1111/j.1349-7006.2009.01177.x. Epub 2009 Apr 22.
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Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis.TRAIL诱导的细胞凋亡中细胞间变异性的非遗传起源
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Cell biology of mRNA decay.mRNA 降解的细胞生物学
使用非等效报告基因对细胞内生化信号网络进行噪声分解
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Quantifying the contribution of chromatin dynamics to stochastic gene expression reveals long, locus-dependent periods between transcriptional bursts.量化染色质动力学对随机基因表达的贡献揭示了转录爆发之间长的、依赖于基因座的时间间隔。
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Synthetic incoherent feedforward circuits show adaptation to the amount of their genetic template.合成非相干前馈电路表现出对其遗传模板数量的适应能力。
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Dynamic proteomics of individual cancer cells in response to a drug.单个癌细胞对药物反应的动态蛋白质组学
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Imaging individual mRNA molecules using multiple singly labeled probes.使用多个单标记探针成像单个mRNA分子。
Nat Methods. 2008 Oct;5(10):877-9. doi: 10.1038/nmeth.1253. Epub 2008 Sep 21.
6
Precision of the Dpp gradient.Dpp梯度的精度。
Development. 2008 Mar;135(6):1137-46. doi: 10.1242/dev.012062.
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A modular network model of aging.衰老的模块化网络模型。
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Increased cell-to-cell variation in gene expression in ageing mouse heart.衰老小鼠心脏中基因表达的细胞间差异增加。
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