健康与疾病中的皮肤免疫哨兵
Skin immune sentinels in health and disease.
作者信息
Nestle Frank O, Di Meglio Paola, Qin Jian-Zhong, Nickoloff Brian J
机构信息
St. John's Institute of Dermatology, King's College London, UK.
出版信息
Nat Rev Immunol. 2009 Oct;9(10):679-91. doi: 10.1038/nri2622. Epub 2009 Sep 18.
Abstract
Human skin and its immune cells provide essential protection of the human body from injury and infection. Recent studies reinforce the importance of keratinocytes as sensors of danger through alert systems such as the inflammasome. In addition, newly identified CD103(+) dendritic cells are strategically positioned for cross-presentation of skin-tropic pathogens and accumulating data highlight a key role of tissue-resident rather than circulating T cells in skin homeostasis and pathology. This Review focuses on recent progress in dissecting the functional role of skin immune cells in skin disease.
摘要
人类皮肤及其免疫细胞为人体提供了免受损伤和感染的重要保护。最近的研究通过诸如炎性小体等警报系统，强化了角质形成细胞作为危险传感器的重要性。此外，新发现的CD103(+)树突状细胞处于战略性位置，可对嗜皮肤病原体进行交叉呈递，并且越来越多的数据突出了组织驻留而非循环T细胞在皮肤稳态和病理过程中的关键作用。本综述重点关注剖析皮肤免疫细胞在皮肤疾病中的功能作用方面的最新进展。
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