Division of Geriatric, S. John-Addolorata Hospital, Rome, Italy.
Arch Gerontol Geriatr. 2009;49 Suppl 1:185-94. doi: 10.1016/j.archger.2009.09.028.
Inflammation is believed to play a pivotal role in dementia, but its role is still unclear. The aim of our study was to analyze the interplay among markers of inflammation, such as fibrinogen and high CRP levels, and dementia. First, we performed a cross-sectional study comparing markers of inflammation between 99 patients affected by dementia (mean age: 83.0+/-0.6 years) and 99 controls (mean age: 83.9+/-0.7 years). Then, we analyzed the relationship between inflammation and dementia in the same population composed by 34 Alzheimer's disease (AD) patients (mean age: 83.4+/-0.8 years), 64 vascular dementia (VaD) patients (mean age: 82.7+0.8 years) and 99 controls. Patients affected by dementia had higher CRP levels than controls (2.6+/-+/-0.2 vs. 0.7 + 0.1 p < 0.001, respectively). AD patients had higher CRP levels than VaD patients (4.2 + 0.6 vs. 1.7+/-0.2, p < 0.001, respectively). Stepwise multiple logistic regression analysis showed that dementia (odds ratio=OR=4.965, 95% confidence interval=Cl=1.402-13.23, p=0.004), fibrinogen (OR=1.011, Cl=1.007-1.015, p<0.001), and age (OR=1.158, Cl=1.063-1.261, p<0.001) are independently correlated with high levels of CRP. The study suggests that inflammation may have a pathogenetic role in AD.
炎症被认为在痴呆中起关键作用，但作用仍不清楚。我们的研究旨在分析炎症标志物（如纤维蛋白原和高 CRP 水平）与痴呆之间的相互作用。首先，我们进行了一项横断面研究，比较了 99 例痴呆患者（平均年龄：83.0+/-0.6 岁）和 99 例对照者（平均年龄：83.9+/-0.7 岁）之间炎症标志物。然后，我们分析了同一人群中炎症与痴呆之间的关系，该人群由 34 例阿尔茨海默病（AD）患者（平均年龄：83.4+/-0.8 岁）、64 例血管性痴呆（VaD）患者（平均年龄：82.7+0.8 岁）和 99 例对照者组成。痴呆患者的 CRP 水平高于对照组（2.6+/-+/-0.2 vs. 0.7+0.1，p<0.001）。AD 患者的 CRP 水平高于 VaD 患者（4.2+0.6 vs. 1.7+/-0.2，p<0.001）。逐步多元逻辑回归分析显示，痴呆（优势比[OR]=4.965，95%置信区间[Cl]=1.402-13.23，p=0.004）、纤维蛋白原（OR=1.011，Cl=1.007-1.015，p<0.001）和年龄（OR=1.158，Cl=1.063-1.261，p<0.001）与 CRP 水平升高独立相关。该研究表明，炎症可能在 AD 中具有发病机制作用。
