永生化人脑内皮细胞系HCMEC/D3作为血脑屏障模型，有助于对新型隐球菌引起的中枢神经系统感染进行体外研究。
Immortalized human brain endothelial cell line HCMEC/D3 as a model of the blood-brain barrier facilitates in vitro studies of central nervous system infection by Cryptococcus neoformans.
作者信息
Vu Kiem, Weksler Babette, Romero Ignacio, Couraud Pierre-Olivier, Gelli Angie
机构信息
Department of Pharmacology, School of Medicine, University of California, Genome and Biomedical Sciences Facility, Davis, CA, USA.
出版信息
Eukaryot Cell. 2009 Nov;8(11):1803-7. doi: 10.1128/EC.00240-09. Epub 2009 Sep 18.
Abstract
Cryptococcus neoformans cells must cross the blood-brain barrier prior to invading the central nervous system. Here we demonstrate that the immortalized human brain endothelial cell line HCMEC/D3 is a useful alternative to primary brain endothelial cells as a model of the blood-brain barrier for studies of central nervous system infection.
摘要
新型隐球菌细胞在侵入中枢神经系统之前必须穿过血脑屏障。在此，我们证明永生化人脑内皮细胞系HCMEC/D3作为血脑屏障模型，可替代原代脑内皮细胞用于中枢神经系统感染的研究。
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