Bastos Deborah H M, Rogero Marcelo M, Arêas José Alfredo G
Departamento de Nutrição, Faculdade de Saúde Pública, Universidade de São Paulo Av. Doutor Arnaldo, 715, 2o andar 01246-904 -- São Paulo, SP, Brasil.
Arq Bras Endocrinol Metabol. 2009 Jul;53(5):646-56. doi: 10.1590/s0004-27302009000500017.
It is largely accepted the important role of food and feeding habits on health maintenance and development of non transmissible chronic diseases (NTCD). Epidemiologic evidences show that increasing vegetable consumption positively impacts health. On the other hand, in vivo and in vitro studies in animals show that non-nutrient bioactive food substances partly explain the role of food on the maintenance of health and on the risk reduction of these diseases. The modulation of gene expression of proteins that are involved in the cellular signaling pathways of NTCD is an important mechanism of the bioactive food substances, indicating their importance in disease prevention. Bioavailability, metabolic routes and the action of the resultant metabolites of bioactive food compounds are important aspects that may affect NTCD. All these aspects have actively been investigated in the last years and resulted in a greater understanding of the beginning, progression and prevention of NTCD. This review aimed at discussing the involved mechanisms of the inflammatory response induced by obesity and the role of bioactive food compounds in modulating such response.
人们普遍认为食物和饮食习惯在维持健康以及非传染性慢性病（NTCD）的发展中起着重要作用。流行病学证据表明，增加蔬菜摄入量对健康有积极影响。另一方面，动物体内和体外研究表明，非营养性生物活性食物物质部分解释了食物在维持健康和降低这些疾病风险方面的作用。调节参与NTCD细胞信号通路的蛋白质的基因表达是生物活性食物物质的重要机制，表明它们在疾病预防中的重要性。生物活性食物化合物的生物利用度、代谢途径及其代谢产物的作用是可能影响NTCD的重要方面。在过去几年中，所有这些方面都得到了积极研究，从而对NTCD的发生、发展和预防有了更深入的了解。本综述旨在讨论肥胖诱导的炎症反应的相关机制以及生物活性食物化合物在调节这种反应中的作用。
