Huhn C, Nerl C, Siebert A, Högl L, Doering W, Kaboth W, Eichenlaub D
II. Medizinische Abteilung, Städtisches Krankenhaus München-Schwabing.
Klin Wochenschr. 1990 Sep 3;68(17):853-6. doi: 10.1007/BF01662781.
In 36 HIV seropositive patients with the clinical manifestation of AIDS and a suspected Pneumocystis carinii infection, lymphocyte subpopulations were analyzed in the peripheral blood (PBL) and compared with the results of the bronchoalveolar lavage (BAL). Of those 36 patients, 29 showed a highly abnormal CD4/CD8 ratio in both the PBL and the BAL. The clinical course of these 29 patients was unpredictable. In seven patients, however, the CD4/CD8 ratio in the BAL was normal or only slightly altered, despite a highly abnormal CD4/CD8 ratio in the PBL. Five of these seven patients improved greatly during the clinical course. The positive outcome of the clinical course was even more strongly correlated with the number of macrophages in the BAL. Twelve of the 36 patients showed normal or only slightly changed numbers of macrophages in the BAL. Eleven of these twelve patients (92%) improved rapidly during antibiotic therapy, while the clinical course was unpredictable in patients with markedly reduced macrophage counts in the BAL.
在36例有艾滋病临床表现且疑似卡氏肺孢子虫感染的HIV血清阳性患者中，分析了外周血（PBL）中的淋巴细胞亚群，并与支气管肺泡灌洗（BAL）结果进行比较。在这36例患者中，29例在PBL和BAL中均显示CD4/CD8比值高度异常。这29例患者的临床病程不可预测。然而，7例患者尽管PBL中的CD4/CD8比值高度异常，但BAL中的CD4/CD8比值正常或仅略有改变。这7例患者中有5例在临床病程中显著改善。临床病程的阳性结果与BAL中巨噬细胞数量的相关性更强。36例患者中有12例BAL中的巨噬细胞数量正常或仅略有变化。这12例患者中有11例（92%）在抗生素治疗期间迅速改善，而BAL中巨噬细胞计数明显减少的患者临床病程不可预测。
