收缩压升高与高胆固醇血症对儿童及青少年颈动脉内膜中层厚度的协同作用。
Synergistic effects of elevated systolic blood pressure and hypercholesterolemia on carotid intima-media thickness in children and adolescents.
作者信息
Krebs Andreas, Schmidt-Trucksäss Arno, Alt Janine, Doerfer Jürgen, Krebs Kristin, Winkler Karl, Schwab Karl Otfried
机构信息
Department of Pediatrics and Adolescents Medicine, University Hospital, Mathilden Street 1, 79106 Freiburg, Germany.
出版信息
Pediatr Cardiol. 2009 Nov;30(8):1131-6. doi: 10.1007/s00246-009-9510-6.
This study aimed to investigate the synergistic effects of elevated systolic blood pressure (SBP) and hypercholesterolemia on carotid intima-media thickness (cIMT). For this study, 60 children with hypercholesterolemia and 40 healthy control children were divided into four subgroups: hypercholesterolemic children with normal (<90th percentile) or elevated (>or= 90th percentile) SBP and control children with normal or elevated SBP. The highest mean and maximal cIMT values were found in the hypercholesterolemic children with elevated SBP and were significantly different from those of all the other groups. The synergistic effects of elevated SBP and hypercholesterolemia lead to a significant increase in cIMT as a subclinical sign of early atherosclerosis.
本研究旨在探讨收缩压升高（SBP）与高胆固醇血症对颈动脉内膜中层厚度（cIMT）的协同作用。在本研究中，60名高胆固醇血症儿童和40名健康对照儿童被分为四个亚组：SBP正常（<第90百分位数）或升高（≥第90百分位数）的高胆固醇血症儿童，以及SBP正常或升高的对照儿童。SBP升高的高胆固醇血症儿童的平均cIMT值和最大cIMT值最高，且与所有其他组有显著差异。SBP升高与高胆固醇血症的协同作用导致cIMT显著增加，这是早期动脉粥样硬化的亚临床征象。
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