Department of ENT, York Hospital, York, UK.
Int J Clin Pract. 2009 Oct;63(10):1526-30. doi: 10.1111/j.1742-1241.2009.02045.x.
Otosclerosis is a bone dystrophy localised to the inner ear and the stapes footplate. Otosclerosis is a frequent cause of deafness in adults. The patient with otosclerosis typically presents with a history of slowly progressive conductive or mixed hearing loss that is usually bilateral and often asymmetric, usually between the ages of 15 and 45 years. The disease is characterised by alternating phases of bone resorption and formation. The majority of studies on families with otosclerosis suggest an autosomal dominant mode of inheritance with incomplete penetrance.
耳硬化症是一种局限于内耳和镫骨底板的骨营养不良。耳硬化症是成年人耳聋的常见原因。耳硬化症患者通常表现为进行性或混合性听力损失的病史，通常为双侧，且常不对称，发病年龄通常在 15 至 45 岁之间。该病的特征是骨吸收和形成交替进行。大多数关于耳硬化症家族的研究表明，该病呈不完全外显的常染色体显性遗传模式。
