利用人类树突状细胞亚群设计新型疫苗。
Harnessing human dendritic cell subsets to design novel vaccines.
作者信息
Banchereau Jacques, Klechevsky Eynav, Schmitt Nathalie, Morita Rimpei, Palucka Karolina, Ueno Hideki
机构信息
Baylor Institute for Immunology Research, Dallas, TX 75204, USA.
出版信息
Ann N Y Acad Sci. 2009 Sep;1174:24-32. doi: 10.1111/j.1749-6632.2009.04999.x.
Abstract
Dendritic cells (DCs) orchestrate a repertoire of immune responses that endow resistance to infection and tolerance to self. DC plasticity and subsets are prominent determinants of the quality of elicited immune responses. Different DC subsets display different receptors and surface molecules and express different sets of cytokines/chemokines, all of which lead to distinct immunological outcomes. Recent findings on human DC subsets and their functional specialization have provided insights for the design of novel human vaccines.
摘要
树突状细胞（DCs）协调一系列免疫反应，赋予机体抗感染能力和自身耐受性。DC的可塑性和亚群是所引发免疫反应质量的重要决定因素。不同的DC亚群表现出不同的受体和表面分子，并表达不同的细胞因子/趋化因子组合，所有这些都会导致不同的免疫结果。关于人类DC亚群及其功能特化的最新研究结果为新型人类疫苗的设计提供了思路。
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