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Immunity against cyclin B1 tumor antigen delays development of spontaneous cyclin B1-positive tumors in p53 (-/-) mice.针对细胞周期蛋白B1肿瘤抗原的免疫反应可延缓p53基因敲除小鼠自发的细胞周期蛋白B1阳性肿瘤的发展。
Ann N Y Acad Sci. 2009 Sep;1174:68-73. doi: 10.1111/j.1749-6632.2009.04941.x.
2
Healthy individuals have T-cell and antibody responses to the tumor antigen cyclin B1 that when elicited in mice protect from cancer.健康个体对肿瘤抗原细胞周期蛋白B1具有T细胞和抗体反应，在小鼠中引发这种反应可预防癌症。
Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14010-5. doi: 10.1073/pnas.0903225106. Epub 2009 Aug 3.
3
Immune recognition of cyclin B1 as a tumor antigen is a result of its overexpression in human tumors that is caused by non-functional p53.细胞周期蛋白B1作为一种肿瘤抗原被免疫识别，是由于其在人类肿瘤中因p53功能缺失而过度表达的结果。
Mol Immunol. 2002 May;38(12-13):981-7. doi: 10.1016/s0161-5890(02)00026-3.
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J Exp Med. 2001 Nov 5;194(9):1313-23. doi: 10.1084/jem.194.9.1313.
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CD8 T-cell responses against cyclin B1 in breast cancer patients with tumors overexpressing p53.在肿瘤中p53过表达的乳腺癌患者中，针对细胞周期蛋白B1的CD8 T细胞反应。
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Identification of the p33(ING1)-regulated genes that include cyclin B1 and proto-oncogene DEK by using cDNA microarray in a mouse mammary epithelial cell line NMuMG.通过在小鼠乳腺上皮细胞系NMuMG中使用cDNA微阵列来鉴定包括细胞周期蛋白B1和原癌基因DEK在内的p33(ING1)调控基因。
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Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2147-52. doi: 10.1073/pnas.96.5.2147.
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T cell-dependent antibody responses against aberrantly expressed cyclin B1 protein in patients with cancer and premalignant disease.癌症和癌前疾病患者针对异常表达的细胞周期蛋白B1蛋白的T细胞依赖性抗体反应。
Clin Cancer Res. 2005 Feb 15;11(4):1521-6. doi: 10.1158/1078-0432.CCR-04-0538.

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本文引用的文献

1
Overexpression of cyclin B1 in human esophageal squamous cell carcinoma cells induces tumor cell invasive growth and metastasis.细胞周期蛋白B1在人食管鳞状细胞癌细胞中的过表达诱导肿瘤细胞侵袭性生长和转移。
Carcinogenesis. 2008 Feb;29(2):307-15. doi: 10.1093/carcin/bgm269. Epub 2007 Nov 28.
2
Prognostic implications of cyclin B1, p34cdc2, p27(Kip1) and p53 expression in gastric cancer.细胞周期蛋白B1、p34cdc2、p27（Kip1）和p53在胃癌中的表达对预后的影响
Yonsei Med J. 2007 Aug 31;48(4):694-700. doi: 10.3349/ymj.2007.48.4.694.
3
Cyclin B1 is commonly expressed in the cytoplasm of primary human acute myelogenous leukemia cells and serves as a leukemia-associated antigen associated with autoantibody response in a subset of patients.细胞周期蛋白B1通常在原发性人类急性髓性白血病细胞的细胞质中表达，并作为一种与部分患者自身抗体反应相关的白血病相关抗原。
Eur J Haematol. 2007 Sep;79(3):210-25. doi: 10.1111/j.1600-0609.2007.00899.x. Epub 2007 Jul 26.
4
Cell cycle and apoptosis regulators in Spitz nevi: comparison with melanomas and common nevi.Spitz痣中的细胞周期和凋亡调节因子：与黑色素瘤和普通痣的比较。
J Am Acad Dermatol. 2007 May;56(5):815-24. doi: 10.1016/j.jaad.2006.09.015.
5
Nuclear cyclin B1 in human breast carcinoma as a potent prognostic factor.人乳腺癌中的核周期蛋白B1作为一种有效的预后因素。
Cancer Sci. 2007 May;98(5):644-51. doi: 10.1111/j.1349-7006.2007.00444.x. Epub 2007 Mar 14.
6
Cyclin B1 is useful to predict occult cervical lymph node metastases in tongue carcinoma.细胞周期蛋白B1有助于预测舌癌患者隐匿性颈部淋巴结转移情况。
J Exp Clin Cancer Res. 2006 Sep;25(3):351-6.
7
Expression profiling of cyclin B1 and D1 in cervical carcinoma.细胞周期蛋白B1和D1在宫颈癌中的表达谱分析
Exp Oncol. 2006 Mar;28(1):44-8.
8
Cyclin B1 and other cyclins as tumor antigens in immunosurveillance and immunotherapy of cancer.细胞周期蛋白B1及其他细胞周期蛋白作为癌症免疫监视和免疫治疗中的肿瘤抗原。
Cancer Res. 2006 Jan 1;66(1):6-9. doi: 10.1158/0008-5472.CAN-05-3389.
9
Cyclin B1 expression is an independent prognostic marker for poor outcome in diffuse large B-cell lymphoma.细胞周期蛋白B1的表达是弥漫性大B细胞淋巴瘤预后不良的独立预后标志物。
Oncol Rep. 2005 Dec;14(6):1461-7.
10
Recycling the cell cycle: cyclins revisited.细胞周期的循环利用：细胞周期蛋白再探讨
Cell. 2004 Jan 23;116(2):221-34. doi: 10.1016/s0092-8674(03)01080-8.

针对细胞周期蛋白B1肿瘤抗原的免疫反应可延缓p53基因敲除小鼠自发的细胞周期蛋白B1阳性肿瘤的发展。

Immunity against cyclin B1 tumor antigen delays development of spontaneous cyclin B1-positive tumors in p53 (-/-) mice.

作者信息

Vella Laura A, Yu Min, Phillips Amy B, Finn Olivera J

机构信息

Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA.

出版信息

Ann N Y Acad Sci. 2009 Sep;1174:68-73. doi: 10.1111/j.1749-6632.2009.04941.x.

DOI:10.1111/j.1749-6632.2009.04941.x
PMID:19769738
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3472441/
Abstract

We previously identified cyclin B1-specific T cells and antibodies in cancer patients with cyclin B1-positive (+) tumors and also in some healthy individuals. We also demonstrated that these responses may be important in cancer immunosurveillance by showing that vaccination against cyclin B1 prevents growth of transplantable cyclin B1(+) tumors in mice. Constitutive overexpression of cyclin B1 was determined to correlate with the lack of p53 function. This allowed us to use p53(-/-) mice as a model that better approximates human disease. These p53(-/-) mice spontaneously develop cyclin B1(+) tumors. At 5-6 weeks of age, when the mice were still healthy with no evidence of tumor, they received the cyclin B1 vaccine and were then observed for tumor growth. We demonstrate that cyclin B1 vaccination delays spontaneous cyclin B1(+) tumor growth and increases median survival of tumor-bearing p53(-/-) mice.

摘要

我们之前在细胞周期蛋白B1阳性（+）肿瘤的癌症患者以及一些健康个体中鉴定出了细胞周期蛋白B1特异性T细胞和抗体。我们还通过表明针对细胞周期蛋白B1的疫苗接种可阻止小鼠体内可移植的细胞周期蛋白B1（+）肿瘤生长，证明了这些反应在癌症免疫监视中可能很重要。细胞周期蛋白B1的组成型过表达被确定与p53功能缺失相关。这使我们能够使用p53（-/-）小鼠作为更接近人类疾病的模型。这些p53（-/-）小鼠会自发发展出细胞周期蛋白B1（+）肿瘤。在5至6周龄时，当小鼠仍健康且无肿瘤迹象时，它们接受了细胞周期蛋白B1疫苗接种，然后观察肿瘤生长情况。我们证明，细胞周期蛋白B1疫苗接种可延迟细胞周期蛋白B1（+）肿瘤的自发生长，并提高荷瘤p53（-/-）小鼠的中位生存期。