[5-氟尿嘧啶和硫磷酰胺对扎伊德氏肝癌磷酸酶活性和组分含量的影响]
[Effect of 5-fluorouracil and thiophosphamide on the activity and fractional content of phosphatases of Zajdela hepatoma].
作者信息
Tret'iakov A V, Riazanov E M, Filov V A
出版信息
Vopr Onkol. 1977;23(3):54-9.
PMID:197707
Abstract
The administration of different types of antitumor drugs is found to lead to a decrease in total activity of phosphatases in mitochondrial, lysosomal and microsomal fraction of Zajdela hepatoma cells, the free activity being enhanced. The isoenzyme pattern of phosphatases in soluble fraction is influenced too. The results suggest that different antitumor drugs cause a uniform response in tumor cells, manifested in disorders in the protein synthesizing system and membranes of subcellular particles involved.
摘要
已发现给予不同类型的抗肿瘤药物会导致Zajdela肝癌细胞线粒体、溶酶体和微粒体部分磷酸酶的总活性降低，而游离活性增强。可溶性部分磷酸酶的同工酶模式也受到影响。结果表明，不同的抗肿瘤药物在肿瘤细胞中引起一致的反应，表现为参与蛋白质合成系统和亚细胞颗粒膜的紊乱。
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