Han Jin, Wan Haitong, Ge Lijun, Zhu Zhenhong, Guo Ying, Zhang Yuyan, Li Jinhui
Traditional Chinese Medicine University of Zhejiang, Institute of Cardio-Cerebrovascular Diseases, Hangzhou 310053, China.
Zhongguo Zhong Yao Za Zhi. 2009 Jun;34(11):1422-5.
To observe the effect of 3'-methoxy puerarin on cerebral infarction volume and free radical change of focal cerebral ischemia-reperfusion injury in rats and discuss the protective effect of 3'-methoxy puerarin on the cerebral ischemic/ reperfusion injury.
The thread method was used to induce middle cerebral artery embolization, to establish the focal cerebral ischemia-reperfusion model. Rats were divided into five groups: the sham and model group, the two-dose group (5, 10 mg x kg(-1) x d(-1)) of 3'-methoxy puerarin and nimodipine group (5 mg x kg(-1) x d(-1)). The behavior changes and volume of cerebral infarction were observed, and the leves of SOD and the content of MDA were measured.
3'-methoxy puerarin could significantly improve the symptoms of neurological deficit and reduce the infarct volume, and increased SOD activity and reduced the content of MDA of cortex in cerebral ischemia-reperfusion injury rat, the action of 10 mg x kg(-1) of 3'-methoxy puerarin is more remarkable.
3'-methoxy puerarin has protective effect on focal cerebral ischemia-reperfusion injury in rat.
观察3'-甲氧基葛根素对大鼠局灶性脑缺血再灌注损伤脑梗死体积及自由基变化的影响，探讨3'-甲氧基葛根素对脑缺血/再灌注损伤的保护作用。
采用线栓法诱导大脑中动脉栓塞，建立局灶性脑缺血再灌注模型。将大鼠分为五组：假手术组、模型组、3'-甲氧基葛根素两个剂量组（5、10mg·kg-1·d-1）和尼莫地平组（5mg·kg-1·d-1）。观察行为变化及脑梗死体积，测定超氧化物歧化酶（SOD）水平和丙二醛（MDA）含量。
3'-甲氧基葛根素能显著改善神经功能缺损症状，减少梗死体积，增加脑缺血再灌注损伤大鼠皮层SOD活性，降低MDA含量，3'-甲氧基葛根素10mg·kg-1的作用更显著。
3'-甲氧基葛根素对大鼠局灶性脑缺血再灌注损伤具有保护作用。
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