Taylor Erik N, Webster Thomas J
Nanomedicine Laboratories, Division of Engineering, and Department of Orthopaedics, Brown University, Providence, RI 02912, USA.
Int J Nanomedicine. 2009;4:145-52. Epub 2009 Sep 10.
As with all surgical procedures, implantation comes with the added risk of infection. The goal of this in vitro study was to explore the use of superparamagnetic iron oxide nanoparticles (SPION) as a multifunctional platform to prevent biofilm formation. Results showed for the first time decreased Staphylococcus epidermidis numbers when exposed to 100 microg/ml of SPION for 12 hours and this trend continued for up to 48 hours. Prevention of colony assembly, a prerequisite to biofilm formation, was also observed at lower SPION dosages of 10 microg/ml after 12 hours. Coupled with previous studies demonstrating enhanced bone cell functions in the presence of the same concentration of SPION, the present results provided much promise for the use of SPION for numerous anti-infection orthopedic applications.
与所有外科手术一样，植入会带来额外的感染风险。这项体外研究的目的是探索使用超顺磁性氧化铁纳米颗粒（SPION）作为多功能平台来预防生物膜形成。结果首次表明，当表皮葡萄球菌暴露于100微克/毫升的SPION中12小时后，其数量减少，并且这种趋势持续长达48小时。在12小时后，在较低的10微克/毫升SPION剂量下也观察到了对菌落聚集的预防，而菌落聚集是生物膜形成的前提条件。结合先前的研究表明在相同浓度的SPION存在下骨细胞功能增强，目前的结果为将SPION用于众多抗感染骨科应用提供了很大的前景。
