Department of Symptom Control and Palliative Care, Cross Cancer Institute, Alberta, Canada.
J Pain Symptom Manage. 2009 Nov;38(5):785-96. doi: 10.1016/j.jpainsymman.2009.03.006. Epub 2009 Sep 23.
The primary aim of this study was to examine the association between physical activity and quality of life (QoL) in cancer patients receiving palliative care. Fifty advanced cancer patients aged 18 years or older with clinician-estimated life expectancy of 3-12 months and Palliative Performance Status Scale scores greater than 30% were recruited from an outpatient palliative care clinic and palliative home care. Participants completed a cross-sectional survey by means of face-to-face interview assessing self-reported QoL (McGill Quality of Life Questionnaire [MQOL]), self-reported physical function (Late-Life Function and Disability Instrument), symptoms (Edmonton Symptom Assessment System), and physical activity behavior. Seventy-six percent (38 of 50) of the participants were deceased at the time of data analysis, with a median survival of 104 days from time of survey to time of death. Walking was the most common reported physical activity. Analyses of variance indicated that participants who reported walking more than 30 minutes per day also reported higher existential subscores (+/-0.8 [95% CI, 0.0-1.5]; P=0.045), support subscores (+/-0.7 [95% CI, 0.1-1.4]; P=0.027), and total scores (+/-0.5 [95% CI, 0.0-0.9]; P=0.046) on the MQOL. There were no significant differences for self-reported physical function or symptoms. Our findings show a significant positive association between physical activity and QoL scores in this sample of patients with advanced cancer. A pilot intervention trial testing the causal effects of physical activity on QoL in cancer patients receiving palliative care is warranted.
本研究的主要目的是探讨接受姑息治疗的癌症患者的体力活动与生活质量（QoL）之间的关系。从姑息治疗门诊和姑息治疗家庭护理中招募了 50 名年龄在 18 岁或以上、临床医生估计预期寿命为 3-12 个月且姑息治疗表现状态量表评分大于 30%的晚期癌症患者。参与者通过面对面访谈完成了一项横断面调查，评估了自我报告的 QoL（麦吉尔生活质量问卷[MQOL]）、自我报告的身体功能（晚年功能和残疾量表）、症状（埃德蒙顿症状评估系统）和体力活动行为。在数据分析时，76%（50 名参与者中的 38 名）已经死亡，从调查到死亡的中位生存时间为 104 天。散步是最常见的体力活动。方差分析表明，每天报告散步超过 30 分钟的参与者也报告了更高的存在亚量表得分（+/-0.8[95%CI，0.0-1.5]；P=0.045）、支持亚量表得分（+/-0.7[95%CI，0.1-1.4]；P=0.027）和 MQOL 总分（+/-0.5[95%CI，0.0-0.9]；P=0.046）。自我报告的身体功能或症状没有显著差异。我们的研究结果表明，在这组晚期癌症患者中，体力活动与 QoL 评分之间存在显著的正相关。有必要进行一项试点干预试验，测试体力活动对接受姑息治疗的癌症患者 QoL 的因果影响。
