儿童虐待与 5-HTT 多态性的相互作用：来自社会经济地位低下背景的儿童的自杀意念。
Interaction of child maltreatment and 5-HTT polymorphisms: suicidal ideation among children from low-SES backgrounds.
机构信息
Institute of Child Development, University of Minnesota, 51 East River Road, Minneapolis, MN 55455, USA.
出版信息
J Pediatr Psychol. 2010 Jun;35(5):536-46. doi: 10.1093/jpepsy/jsp078. Epub 2009 Sep 24.
OBJECTIVE
To investigate whether genotypic variation of the serotonin transporter gene-linked promoter region (5-HTTLPR) moderates the effect of maltreatment on suicidal ideation in school-aged children.
METHODS
Eight hundred and fifty low-income children (478 maltreated; 372 non-maltreated) provided DNA samples and self-reported depressive and suicidal symptoms. Genotypes of 5-HTTLPR (s/s or s/l vs. l/l) were determined by fragment analyses.
RESULTS
Higher suicidal ideation was found among maltreated than non-maltreated children; the groups did not differ in 5-HTTLPR genotype frequencies. Children with one to two maltreatment subtypes and s/s or s/l genotypes had higher suicidal ideation than those with the l/l genotype; suicidal ideation did not differ in non-maltreated children or children with three to four maltreatment subtypes based on 5-HTTLPR variation. The results were applicable to emotionally maltreated/neglected and to physically/sexually abused children. Gene-environment interaction was not found for depressive symptoms.
CONCLUSION
The protective effect of the 5-HTTLPR l/l genotype on suicidal ideation was limited to maltreated children experiencing fewer subtypes.
目的
探讨 5-羟色胺转运体基因启动子区域（5-HTTLPR）的基因型变异是否能调节虐待对学龄儿童自杀意念的影响。
方法
850 名低收入儿童（478 名受虐待；372 名未受虐待）提供了 DNA 样本，并自我报告了抑郁和自杀症状。5-HTTLPR（s/s 或 s/l 与 l/l）的基因型通过片段分析确定。
结果
受虐待的儿童比未受虐待的儿童自杀意念更高；两组在 5-HTTLPR 基因型频率上没有差异。有一到两种虐待亚型和 s/s 或 s/l 基因型的儿童比具有 l/l 基因型的儿童自杀意念更高；基于 5-HTTLPR 变异，未受虐待的儿童或有三到四种虐待亚型的儿童的自杀意念没有差异。结果适用于情感虐待/忽视和身体/性虐待的儿童。基因-环境相互作用对抑郁症状没有影响。
结论
5-HTTLPR l/l 基因型对自杀意念的保护作用仅限于经历较少亚型的受虐待儿童。
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