Gaston Romina Lopez, Best David, Manning Victoria, Day Ed
Department of Psychiatry, University of Birmingham, The Barberry Vincent Drive, Birmingham, UK.
Harm Reduct J. 2009 Sep 25;6:26. doi: 10.1186/1477-7517-6-26.
Naloxone has been evidenced widely as a means of reducing mortality resulting from opiate overdose, yet its distribution to drug users remains limited. However, it is drug users who are most likely to be available to administer naloxone at the scene and who have been shown to be willing and motivated to deliver this intervention. The current study builds on a national training evaluation in England by assessing 6-month outcome data collected primarily in one of the participating centres.
Seventy patients with opioid dependence syndrome were trained in the recognition and management of overdoses in Birmingham (n = 66) and London (n = 4), and followed up six months after receiving naloxone. After successful completion of the training, participants received a supply of 400 micrograms of naloxone (in the form of a preloaded syringe) to take home. The study focused on whether participating users still had their naloxone, whether they retained the information, whether they had witnessed an overdose and whether they had naloxone available and were still willing to use it in the event of overdose.
RESULTS & DISCUSSION: The results were mixed - although the majority of drug users had retained the naloxone prescribed to them, and retention of knowledge was very strong in relation to overdose recognition and intervention, most participants did not carry the naloxone with them consistently and consequently it was generally not available if they witnessed an overdose. The paper discusses the reasons for the reluctance to carry naloxone and potential opportunities for how this might be overcome. Future issues around training and support around peer dissemination are also addressed.
Our findings confirm that training of drug users constitutes a valuable resource in the management of opiate overdoses and growth of peer interventions that may not otherwise be recognised or addressed. Obstacles have been identified at individual (transportability, stigma) and at a systems level (police involvement, prescription laws). Training individuals does not seem to be sufficient for these programmes to succeed and a coherent implementation model is necessary.
纳洛酮已被广泛证明是降低阿片类药物过量致死率的一种手段,但其在吸毒者中的分发仍然有限。然而,最有可能在现场使用纳洛酮进行给药的正是吸毒者,并且研究表明他们愿意且有动力实施这种干预措施。本研究基于英国的一项全国性培训评估,通过评估主要在其中一个参与中心收集的6个月结果数据展开。
70名阿片类药物依赖综合征患者在伯明翰(n = 66)和伦敦(n = 4)接受了过量用药识别与管理方面的培训,并在接受纳洛酮治疗6个月后进行随访。培训成功完成后,参与者会得到一份400微克纳洛酮(预装注射器形式)带回家。该研究聚焦于参与的使用者是否仍持有纳洛酮、是否记住了相关信息、是否目睹过过量用药情况以及是否有纳洛酮可用且在过量用药时仍愿意使用它。
结果喜忧参半——尽管大多数吸毒者保留了开给他们的纳洛酮,并且在过量用药识别和干预方面知识保留情况良好,但大多数参与者并未始终随身携带纳洛酮,因此如果他们目睹过量用药情况,纳洛酮通常无法使用。本文讨论了不愿携带纳洛酮的原因以及克服这一问题的潜在机会。还探讨了围绕同伴传播的培训和支持方面的未来问题。
我们的研究结果证实,对吸毒者进行培训是管理阿片类药物过量及发展同伴干预措施的宝贵资源,否则这些措施可能无法得到认可或实施。已在个人层面(可携带性、污名化)和系统层面(警方介入、处方法律)识别出障碍。仅对个人进行培训似乎不足以使这些项目取得成功,需要一个连贯的实施模式。