Liang Yong, Li Hui, Hou Sheng-cai, Hu Bin, Miao Jin-bai, Li Tong, You Bin, Yu Li-xin, Wang Lei, Chen Qi-rui, Chen Xing
Department of Thoracic Surgery, Beijing Chao-Yang Hospital, Beijing 100020, China.
Zhonghua Wai Ke Za Zhi. 2009 Jul 15;47(14):1061-3.
To study the relationship between expression of galectin-3 (Gal-3) and osteopontin (OPN) in occult metastasis in non-small cell lung cancer.
Forty-six patients of non-small cell lung cancer (NSCLC) from January 2006 to October 2007 were selected. There were 28 males and 18 females, aged from 33 to 77 years old. The levels of lung tissues Gal-3 and OPN were detected by RT-PCR, and the levels of blood plasma's were measured by ELISA.
There were 12 patients who had metastasized. In un-metastasis group the Gal-3 and OPN mRNA expression levels were significantly lower than that in metastasis group: mean value were 0.07 +/- 0.17 and 0.17 +/- 0.25 in un-metastasis group, while 0.73 +/- 0.23 and 0.79 +/- 0.24 in metastasis group. Blood plasma levels of Gal-3 (18.8 +/- 7.9) microg/L and OPN (153.5 +/- 63.5) microg/L in NSCLC which were detected from metastasis group were higher than un-metastasis group of (9.2 +/- 5.6) microg/L and (89.2 +/- 24.0) microg/L.
High serum levels of Gal-3 and OPN and high expression of Gal-3 and OPN mRNA in NSCLC are closely related to the occurrence and metastasis of NSCLC. They may be indexes of evaluating the occult metastasis in NSCLC.
研究半乳糖凝集素-3（Gal-3）和骨桥蛋白（OPN）表达与非小细胞肺癌隐匿转移之间的关系。
选取2006年1月至2007年10月间的46例非小细胞肺癌（NSCLC）患者。其中男性28例，女性18例，年龄33至77岁。采用RT-PCR检测肺组织中Gal-3和OPN水平，采用ELISA检测血浆中Gal-3和OPN水平。
有12例发生转移。未转移组Gal-3和OPN mRNA表达水平显著低于转移组：未转移组平均值分别为0.07±0.17和0.17±0.25，而转移组为0.73±0.23和0.79±0.24。转移组检测的NSCLC患者血浆中Gal-3水平（18.8±7.9）μg/L和OPN水平（153.5±63.5）μg/L高于未转移组的（9.2±5.6）μg/L和（89.2±24.0）μg/L。
NSCLC患者血清中高Gal-3和OPN水平以及Gal-3和OPN mRNA高表达与NSCLC的发生和转移密切相关。它们可能是评估NSCLC隐匿转移的指标。
