Department of Pharmacology, Georgetown University, 3900 Reservoir Road, Basic Science Building, Room 309, Washington, DC 20057, USA.
Toxicon. 2010 Feb-Mar;55(2-3):658-61. doi: 10.1016/j.toxicon.2009.09.002. Epub 2009 Sep 23.
Ricin inhibits translation by removal of a specific adenine from 28S RNA. The Ricinus communis genome encodes seven full-length ricin family members. All encoded proteins have the ability of hydrolyzing adenine in 28S rRNA. As expected, these proteins also inhibited an in vitro transcription/translation system. These data show that the ricin gene family contains at least seven members that have the ability to inhibit translation and that may contribute to the toxicity of R. communis.
蓖麻毒素通过从 28S RNA 上移除特定的腺嘌呤来抑制翻译。大蓖麻基因组编码七个全长蓖麻毒素家族成员。所有编码蛋白都具有水解 28S rRNA 中腺嘌呤的能力。正如预期的那样，这些蛋白也抑制了体外转录/翻译系统。这些数据表明，蓖麻毒素基因家族至少包含七个具有抑制翻译能力的成员，这些成员可能有助于大蓖麻的毒性。
