School of Natural Product Studies, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India.
J Ethnopharmacol. 2009 Dec 10;126(3):434-6. doi: 10.1016/j.jep.2009.09.019. Epub 2009 Sep 23.
To investigate the mast cell stabilization and antihistaminic activities of the rhizomes of Curculigo orchioides (COR). Extract of Curculigo orchioides Gaertn. (Fam. Amaryllidaceae) has been reported to possess immunostimulant, and anti-inflammatory potentials. In Indian traditional system of medicine it is also used as anti-asthmatic and anti-inflammatory.
Estimation of histamine release is key parameter for evaluating any target for its anti-allergic potential. The stabilization potential of the alcoholic extract of COR (100-400mg/kg) against mast cell degranulation was studied on isolated mice peritoneal mast cells. The antihistaminic activity was performed by determining the mortality rate of mice upon exposure to compound 48/80 and effect on inhibition of histamine release upon degranulation.
The raised number of intact mast cells intimates that the COR stabilized the mast cell degranulation (60.96+/-1.96%) and percentage antihistaminic potential of the extract (63.58+/-1.8 inhibition at dose of 400mg/kg) and it virtues further work towards the isolation of phytoconstituents from this plant.
This finding provides evidence that COR inhibits mast cell-derived immediate-type allergic reactions and mast cell degranulation.
研究仙茅根茎的肥大细胞稳定和抗组胺活性。仙茅（Amaryllidaceae 科）的提取物已被报道具有免疫刺激和抗炎潜力。在印度传统医学体系中，它也被用作抗哮喘和抗炎药。
评估任何抗过敏目标的关键参数是组胺释放的估计。在分离的小鼠腹腔肥大细胞上研究 COR（100-400mg/kg）的酒精提取物对肥大细胞脱颗粒的稳定潜力。通过测定暴露于化合物 48/80 后小鼠的死亡率以及对脱颗粒时组胺释放抑制的影响来进行抗组胺活性。
完整肥大细胞数量的增加表明 COR 稳定了肥大细胞脱颗粒（60.96+/-1.96%）和提取物的百分抗组胺潜力（63.58+/-1.8%抑制在 400mg/kg 剂量下），这进一步证明了从该植物中分离植物成分的价值。
这一发现提供了证据表明 COR 抑制肥大细胞来源的即刻型过敏反应和肥大细胞脱颗粒。
