Mukherjee Pulok K, Venkatesh P, Ponnusankar S
School of Natural Product Studies, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India.
J Ayurveda Integr Med. 2010 Apr;1(2):100-9. doi: 10.4103/0975-9476.65077.
Traditional systems of medicines need more evidence-based studies on both crude drugs and purified phytomolecules. Utilization of natural products as pharmacological tools could lead to a number of new major therapeutically active metabolites. Lead molecules are further screened for their potential in terms of quality control, safety assessments, and studies about molecular pharmacology and their related properties. Identification, and quality and safety evaluation of natural products, is a fundamental requirement of industry and other organizations dealing with natural health products (NHPs). Marker analysis, based on chemo-profiling and development of characteristic fingerprints for individual plants, could help to develop uniform standardization tools. Beside such evaluations of clinical parameters, safety profiles as well as drug-herb and herb-herb interactions are the most important parameters for assessment and promotion. With the steady growth of the NHPs, advanced analytical- and mechanism-based screening should be considered for their promotion and value addition in every way for the betterment of healthcare. Thus, there is an urgent need for the development of international co-ordination to promote and develop NHPs, including their assessment, perspectives, pharmacovigilance, and potential harmonization of regulation, quality control and clinical uses.
传统医学体系需要对生药和纯化的植物分子开展更多基于证据的研究。将天然产物用作药理学工具可能会产生许多新的主要治疗活性代谢物。针对先导分子的质量控制、安全性评估以及分子药理学及其相关特性的研究，对其潜力进行进一步筛选。天然产物的鉴定、质量和安全性评估，是从事天然健康产品（NHP）的行业和其他组织的基本要求。基于化学剖析和单个植物特征指纹图谱开发的标志物分析，有助于开发统一的标准化工具。除了对临床参数进行此类评估外，安全性概况以及药物与草药、草药与草药之间的相互作用，是评估和推广的最重要参数。随着天然健康产品的稳步增长，应考虑采用先进的基于分析和机制的筛选方法，从各个方面对其进行推广和增值，以改善医疗保健。因此，迫切需要开展国际协调，以促进和发展天然健康产品，包括其评估、前景、药物警戒以及法规、质量控制和临床用途的潜在协调统一。
