大肠杆菌中 AAA+ 蛋白酶的一般和监管蛋白水解原理。
Principles of general and regulatory proteolysis by AAA+ proteases in Escherichia coli.
机构信息
Zentrum für Molekulare Biologie Heidelberg (ZMBH), DKFZ-ZMBH Alliance, Universität Heidelberg, Im Neuenheimer Feld 282, Heidelberg D-69120, Germany.
出版信息
Res Microbiol. 2009 Nov;160(9):629-36. doi: 10.1016/j.resmic.2009.08.018. Epub 2009 Sep 22.
PMID:19781640
Abstract
General and regulated proteolysis in bacteria is crucial for cellular homeostasis and relies on high substrate specificity of the executing AAA+ proteases. Here we summarize the various strategies that tightly control substrate degradation from both sides: the generation of accessible degrons and their specific recognition by AAA+ proteases and cognate adaptor proteins.
摘要
在细菌中，普遍存在的和调控的蛋白质降解对于细胞内稳态至关重要，这依赖于执行 AAA+蛋白酶对底物的高特异性。在这里，我们总结了从两个方面严格控制底物降解的各种策略：可接近的降解信号的产生及其被 AAA+蛋白酶和同源衔接蛋白的特异性识别。
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