Spahl W, Budzikiewicz H, Geurtsen W
Institute of Organic Chemistry, Universität, München, Germany.
J Dent. 1998 Mar;26(2):137-45. doi: 10.1016/s0300-5712(96)00086-3.
The purpose of our study was to determine the quality and quantity of leachable residual (co)monomers and additives eluted from various commercial dental composite resins after polymerization.
Polymerized specimens from four universal hybrid-type composite resins were eluted for 3 days with methanol resp, water. Then all extracts were analysed by gas chromatography/mass spectrometry or liquid chromatography/mass spectrometry using a particle beam interface.
In all polymerized composite resin specimens, (co)monomers and various additives as well as contaminants from manufacturing processes were identified. Almost every compound detected in the unpolymerized resins could also be identified in the methanol extracts, but only a few of them were found in the water extracts. From these the co-monomer TEGDMA was extracted in quantities higher than those reported to be cytotoxic in primary human oral fibroblast cultures.
From our results we conclude that the extractable quantities of composite resin components should be minimized, either by reducing the mobility of leachable substances within the set material or by applying less water-soluble components. Furthermore, all ingredients of a dental composite should be declared by the manufacturers, in order to identify those substances in a product which may cause adverse side effects in patients and dental personnel.
我们研究的目的是确定聚合后从各种商用牙科复合树脂中洗脱出来的可浸出残留（共）单体和添加剂的质量和数量。
将四种通用混合型复合树脂的聚合标本分别用甲醇和水洗脱3天。然后使用粒子束接口通过气相色谱/质谱或液相色谱/质谱对所有提取物进行分析。
在所有聚合复合树脂标本中，鉴定出了（共）单体、各种添加剂以及制造过程中的污染物。在未聚合树脂中检测到的几乎每种化合物在甲醇提取物中也能被鉴定出来，但在水提取物中只发现了其中少数几种。其中，共单体TEGDMA的提取量高于据报道在原代人口腔成纤维细胞培养中具有细胞毒性的量。
根据我们的结果，我们得出结论，复合树脂成分的可提取量应减至最低限度，要么通过降低可浸出物质在固化材料中的流动性，要么通过使用水溶性较低的成分。此外，牙科复合材料的所有成分应由制造商声明，以便识别产品中那些可能对患者和牙科工作人员造成不良副作用的物质。
