Unit of Restorative Dentistry and Endodontics, Department of Medical, Oral and Biotechnological Sciences, School of Dentistry, "G. D'Annunzio" University Chieti-Pescara, Via dei Vestini, 31, 66100, Chieti, Italy.
Department of Physiology and Biochemistry, Faculty of Physical Education and Sport, Charles University, Prague, Czech Republic.
Clin Oral Investig. 2022 Oct;26(10):6015-6041. doi: 10.1007/s00784-022-04625-4. Epub 2022 Jul 23.
Resin-based materials are applied in every branch of dentistry. Due to their tendency to release substances in the oral environment, doubts have been raised about their actual safety. This review aims to provide a comprehensive analysis of the last decade literature regarding the concentrations of elutable substances released from dental resin-based materials in different type of solvents.
All the literature published on dental journals between January 2010 and April 2022 was searched using international databases (PubMed, Scopus, Web of Science). Due to strict inclusion criteria, only 23 papers out of 877 were considered eligible. The concentration of eluted substances related to surface and volume of the sample was analyzed, considering data at 24 h as a reference. The total cumulative release was examined as well.
The most eluted substances were HEMA, TEGDMA, and BPA, while the less eluted were Bis-GMA and UDMA. Organic solvents caused significantly higher release of substances than water-based ones. A statistically significant inverse correlation between the release of molecules and their molecular mass was observed. A statistically significant positive correlation between the amount of released molecule and the specimen surface area was detected, as well as a weak positive correlation between the release and the specimen volume.
Type of solvent, molecular mass of eluates, and specimen surface and volume affect substances release from materials.
It could be advisable to rely on materials based on monomers with a reduced elution tendency for clinical procedures.
树脂基材料应用于牙科的各个领域。由于其在口腔环境中释放物质的倾向，人们对其实际安全性产生了怀疑。本综述旨在对过去十年中关于牙科树脂基材料在不同类型溶剂中释放的可洗脱物质浓度的文献进行全面分析。
使用国际数据库（PubMed、Scopus、Web of Science）检索 2010 年 1 月至 2022 年 4 月期间发表在牙科期刊上的所有文献。由于严格的纳入标准，在 877 篇论文中只有 23 篇被认为符合条件。分析了与样品表面和体积相关的可洗脱物质的浓度，以 24 小时的数据作为参考。还检查了总的累积释放量。
最易洗脱的物质是 HEMA、TEGDMA 和 BPA，而较不易洗脱的是 Bis-GMA 和 UDMA。有机溶剂比水基溶剂释放的物质明显更多。释放的分子与其分子量之间存在显著的负相关。释放的分子数量与标本表面积之间存在显著正相关，与标本体积之间存在较弱的正相关。
溶剂类型、洗脱物的分子量以及标本的表面积和体积都会影响材料中物质的释放。
对于临床操作，选择洗脱倾向较小的单体基材料可能是明智之举。
