National Food Institute, Technical University of Denmark, Mørkhøj Bygade 19, DK-2860 Søborg, Denmark.
Regul Toxicol Pharmacol. 2010 Mar;56(2):174-92. doi: 10.1016/j.yrtph.2009.09.013. Epub 2009 Sep 24.
The risk assessment of pesticide residues in food is based on toxicological evaluation of the single compounds and no internationally accepted procedure exists for evaluation of cumulative exposure to multiple residues of pesticides in crops, except for a few groups of pesticides sharing a group ADI. However, several attempts have been suggested during the last decade. This paper gives an overview of the various approaches. It is of paramount importance to consider whether there will be either no interaction or interaction between the compounds in the mixture. When there are no interactions several approaches are available for the risk assessment of mixtures of pesticides. However, no single simple approach is available to judge upon potential interactions at the low doses that humans are exposed to from pesticide residues in food. In these cases, PBTK models could be useful as tools to assess combined tissue doses and to help predict potential interactions including thresholds for such effects. This would improve the quality of the risk assessment.
食品中农药残留的风险评估基于对单一化合物的毒理学评价，除了少数几类共享一个 ADI 组的农药外，目前尚无国际公认的程序可用于评估作物中多种农药残留的累积暴露情况。然而，在过去十年中已经提出了几种方法。本文概述了各种方法。至关重要的是要考虑混合物中的化合物之间是否会发生相互作用。当没有相互作用时，可采用几种方法对农药混合物进行风险评估。但是，对于人类从食物中的农药残留中接触到的低剂量的潜在相互作用，目前还没有单一的简单方法可以判断。在这些情况下，基于毒物动力学的定量模型 (PBTK) 可作为评估联合组织剂量和帮助预测潜在相互作用（包括此类效应的阈值）的工具。这将提高风险评估的质量。
