Laboratory of Molecular Toxicology, Institute of Zoology, Chinese Academy of Sciences, 1-5 Beichenxilu Road, Beijing, 100101, P. R. China.
Department of Veterinary Medicine and Animal Science, Beijing University of Agriculture, Beijing, 102206, P. R. China.
BMC Pharmacol Toxicol. 2022 Jul 8;23(1):46. doi: 10.1186/s40360-022-00586-2.
Permethrin is one of the pyrethroid insecticides, which is widely used in agriculture and public health. Although acute toxicity of the insecticide has been studied, the chronic toxicity upon the long-term exposure has not been clear yet. The purpose of the current study is to investigate the organ toxicities of permethrin following its long-term low-dose exposure.
Male Wistar rats were daily administrated orally with permethrin (75 mg/kg body weight/day, gavage) for 90 days, and then the samples of biofluids (blood and urine) and organs including liver and kidney were collected. The serum and urine samples were measured by biochemical assay and the tissues of kidney and liver were examined and analyzed by histopathological method.
The results showed that no change was found in serum and urine biochemical parameters for the toxicity; however, significant changes including hyperchromatic nuclei swollen in the hepatic parenchymal cells and the swelling proximal tubules in the kidneys were observed in the tissue structures of liver and kidneys in the histopathological sections.
These results indicate that low-dose long-term exposure of permethrin can cause chronic toxicity with slight liver and kidney damage.
氯菊酯是拟除虫菊酯类杀虫剂之一，广泛应用于农业和公共卫生领域。尽管已对其急性毒性进行了研究，但长期低剂量暴露的慢性毒性仍不清楚。本研究旨在探讨氯菊酯长期低剂量暴露后的器官毒性。
雄性 Wistar 大鼠经口灌胃给予氯菊酯（75mg/kg 体重/天）90 天，然后采集生物流体（血液和尿液）和器官（肝和肾）样本。通过生化分析检测血清和尿液样本，通过组织病理学方法检查和分析肾和肝组织。
结果表明，血清和尿液生化参数未发生毒性变化；然而，在肝组织和肾组织的组织学切片中观察到肝实质细胞中核染色质深染和肿胀的细胞以及近端肾小管肿胀的明显变化。
这些结果表明，氯菊酯的低剂量长期暴露可引起轻微的肝和肾损伤的慢性毒性。
