Pacific Northwest National Laboratory, Richland, WA 99352, USA.
Talanta. 2009 Nov 15;80(1):403-6. doi: 10.1016/j.talanta.2009.06.054. Epub 2009 Jul 2.
The bionanocomposite film consisting of glucose oxidase/Pt/functional graphene sheets/chitosan (GOD/Pt/FGS/chitosan) for glucose sensing is described. With the electrocatalytic synergy of FGS and Pt nanoparticles to hydrogen peroxide, a sensitive biosensor with a detection limit of 0.6 microM glucose was achieved. The biosensor also has good reproducibility, long-term stability and negligible interfering signals from ascorbic acid and uric acid comparing with the response to glucose. The large surface area and good electrical conductivity of graphene suggests that graphene is a potential candidate as a sensor material. The hybrid nanocomposite glucose sensor provides new opportunity for clinical diagnosis and point-of-care applications.
描述了一种由葡萄糖氧化酶/铂/功能化石墨烯片/壳聚糖（GOD/Pt/FGS/壳聚糖）组成的用于葡萄糖传感的生物纳米复合膜。由于 FGS 和 Pt 纳米粒子对过氧化氢的电催化协同作用，实现了具有 0.6 μM 葡萄糖检测限的灵敏生物传感器。与葡萄糖的响应相比，该生物传感器还具有良好的重现性、长期稳定性和可忽略的抗坏血酸和尿酸的干扰信号。石墨烯的大表面积和良好的导电性表明石墨烯是一种有潜力的传感器材料。该混合纳米复合葡萄糖传感器为临床诊断和即时检测应用提供了新的机会。
