Tecellact, LLC, 1685 Calle Camille, La Jolla, CA 92037, USA.
Curr Opin Biotechnol. 2009 Oct;20(5):563-7. doi: 10.1016/j.copbio.2009.08.008. Epub 2009 Sep 24.
Recent advance in cellular tissue-engineered skin constructs have refined the applications already commercially available, in particular, by the use of genetically modified cells to enhance their properties on the treatment of wounds and to ease the application of epidermis using sprayed keratinocytes. This approach lends itself to use of chimeric epidermis, cultured allogeneic cells, to provide short-term coverage, together with minimally cultured autologous cells for long-term repair. Experimental models of skin include pathological conditions, phenomena such as aging and organogenesis, as in the hair follicle grown from isolated cells in vitro. The recent development of induced pluripotent stem cells raises the possibility of realizing the dream of skin and even limb regeneration shown by animals such as the salamander.
最近，细胞组织工程皮肤构建的进展已经改进了已经商业化的应用，特别是通过使用基因修饰细胞来增强其在治疗伤口方面的特性，并简化使用喷雾角化细胞的表皮应用。这种方法适用于使用嵌合表皮、培养的同种异体细胞来提供短期覆盖，同时使用最少培养的自体细胞进行长期修复。皮肤的实验模型包括病理条件、衰老和器官发生等现象，例如从体外分离细胞中生长的毛囊。诱导多能干细胞的最新发展使得实现皮肤甚至肢体再生的梦想成为可能，这种现象在蝾螈等动物中已经得到了展示。
