Mogensen Mette, Thrane L, Joergensen T M, Andersen P E, Jemec G B E
Department of Dermatology, Faculty of Health Sciences, University of Copenhagen, Roskilde Hospital, Roskilde, Denmark.
Semin Cutan Med Surg. 2009 Sep;28(3):196-202. doi: 10.1016/j.sder.2009.07.002.
Optical coherence tomography (OCT) is an emerging imaging technology based on light reflection. It provides real-time images with up to 2-mm penetration into the skin and a resolution of approximately 10 microm. It is routinely used in ophthalmology. The normal skin and its appendages have been studied, as have many diseases. The method can provide accurate measures of epidermal and nail changes in normal tissue. Skin cancer and other tumors, as well as inflammatory diseases, have been studied and good agreement found between OCT images and histopathological architecture. OCT also allows noninvasive monitoring of morphologic changes in skin diseases and may have a particular role in the monitoring of medical treatment of nonmelanoma skin cancer. The technology is however still evolving and continued technological development will necessitate an ongoing evaluation of its diagnostic accuracy. Several technical solutions are being pursued to further improve the quality of the images and the data provided, and OCT is being integrated in multimodal imaging devices that would potentially be able to provide a quantum leap to the imaging of skin in vivo.
光学相干断层扫描（OCT）是一种基于光反射的新兴成像技术。它能提供实时图像，可穿透皮肤达2毫米，分辨率约为10微米。它在眼科中常规使用。正常皮肤及其附属器已得到研究，许多疾病也进行了研究。该方法能对正常组织中的表皮和指甲变化进行准确测量。皮肤癌和其他肿瘤以及炎症性疾病都已得到研究，并且发现OCT图像与组织病理学结构之间有很好的一致性。OCT还允许对皮肤疾病的形态变化进行无创监测，并且在非黑色素瘤皮肤癌的治疗监测中可能具有特殊作用。然而，该技术仍在不断发展，持续的技术进步将需要对其诊断准确性进行持续评估。正在寻求多种技术解决方案以进一步提高所提供图像和数据的质量，并且OCT正在被集成到多模态成像设备中，这可能会给体内皮肤成像带来巨大飞跃。
