Department of Dermatology and Allergy, Technische Universität München, Munich, Germany.
Chair of Biological Imaging, Technische Universität München, Munich, Germany.
J Eur Acad Dermatol Venereol. 2019 Jun;33(6):1051-1061. doi: 10.1111/jdv.15342. Epub 2019 Apr 5.
In recent years, several non-invasive imaging methods have been introduced to facilitate diagnostics and therapy monitoring in dermatology. The microscopic imaging methods are restricted in their penetration depth, while the mesoscopic methods probe deeper but provide only morphological, not functional, information. 'Raster-scan optoacoustic mesoscopy' (RSOM), an emerging new imaging technique, combines deep penetration with contrast based on light absorption, which provides morphological, molecular and functional information. Here, we compare the capabilities and limitations of currently available dermatological imaging methods and highlight the principles and unique abilities of RSOM. We illustrate the clinical potential of RSOM, in particular for non-invasive diagnosis and monitoring of inflammatory and oncological skin diseases.
近年来，已经引入了几种非侵入性成像方法来促进皮肤科的诊断和治疗监测。微观成像方法受到其穿透深度的限制，而中观方法则探测得更深，但仅提供形态学而不是功能信息。作为一种新兴的新型成像技术，“光栅扫描光声介观成像”（RSOM）结合了基于光吸收的对比度的深穿透能力，从而提供形态学、分子和功能信息。在这里，我们比较了当前可用的皮肤科成像方法的优缺点，并强调了 RSOM 的原理和独特能力。我们说明了 RSOM 的临床潜力，特别是对于非侵入性诊断和监测炎症性和肿瘤性皮肤病。
