Department of Nutrition, Food Science, Physiology and Toxicology, University of Navarra, Pamplona, Spain.
Nutrition. 2010 May;26(5):534-41. doi: 10.1016/j.nut.2009.06.017. Epub 2009 Sep 26.
Oxidative stress has been related to the development of obesity and other features accompanying chronic diseases. Furthermore, dietary antioxidant intake has been suggested to protect against oxidative damage and related clinical complications. Therefore, the aim of this study was to assess the potential associations among dietary total antioxidant capacity (TAC) and several early metabolic syndrome manifestations in healthy young adults.
Anthropometric variables and blood pressure from 153 healthy subjects (20.8+/-2.7 y old) were measured. Dietary intake was assessed by a validated food-frequency questionnaire and a 3-d record, which were also used to calculate TAC and to adjust by daily energy intake. Fasting blood samples were collected for measuring biochemical markers.
Dietary TAC showed positive and significant associations with fiber, folic acid, vitamin A and C, magnesium, selenium, and zinc intakes, after adjusting by sex and daily energy intake. Interestingly, systolic blood pressure, serum glucose, and free fatty acids were also found to be negatively associated with dietary TAC independently of sex and daily energy intake. Also, a relevant relation was found between body mass index and TAC values. Interestingly, after adjusting by sex and daily energy intake, complement factor-3 circulating levels appeared to be negatively and significantly associated with dietary TAC, whereas blood plasminogen activator inhibitor-1 and homocysteine concentrations showed an inverse marginally statistical trend.
These data suggest that dietary TAC may be also a potential early estimate of the risk to develop metabolic syndrome features and that dietary TAC could be a useful research tool in assessing antioxidant intake.
氧化应激与肥胖和其他伴随慢性病的特征有关。此外，饮食中抗氧化剂的摄入被认为可以防止氧化损伤和相关的临床并发症。因此，本研究旨在评估健康年轻成年人的饮食总抗氧化能力（TAC）与几种早期代谢综合征表现之间的潜在关联。
测量了 153 名健康受试者（20.8±2.7 岁）的人体测量变量和血压。通过验证的食物频率问卷和 3 天记录评估饮食摄入，并计算 TAC 并根据每日能量摄入进行调整。采集空腹血样以测量生化标志物。
调整性别和每日能量摄入后，饮食 TAC 与纤维、叶酸、维生素 A 和 C、镁、硒和锌的摄入量呈正相关且有统计学意义。有趣的是，收缩压、血清葡萄糖和游离脂肪酸也与饮食 TAC 呈负相关，而与性别和每日能量摄入无关。此外，体重指数与 TAC 值之间也存在相关关系。有趣的是，调整性别和每日能量摄入后，循环补体因子-3 水平与饮食 TAC 呈负相关，而血纤溶酶原激活物抑制剂-1 和同型半胱氨酸浓度呈负相关趋势。
这些数据表明，饮食 TAC 可能也是代谢综合征特征发生风险的一个潜在早期估计值，饮食 TAC 可能是评估抗氧化剂摄入的有用研究工具。
