Advanced Heart Failure and Cardiac Transplant Service, The Royal Perth Hospital, Wellington Street, Perth, Western Australia 6000, Australia.
J Heart Lung Transplant. 2009 Nov;28(11):1211-4. doi: 10.1016/j.healun.2009.07.013. Epub 2009 Sep 26.
There is much debate over the role of immunosuppression in the treatment of acute and fulminant myocarditis. The low incidence of the condition prevents large numbers of cases for study, and treatment protocols vary greatly between institutions. In this study we add our experience with anti-thymocyte globulin as an adjunct to standard medical therapy for 5 patients presenting with cardiogenic shock due to fulminant myocarditis. All cases were associated with rapid and dramatic improvement in hemodynamic and electrophysiologic abnormalities, returning patients to NYHA Class I and cardiac function to normal or near normal by discharge.
关于免疫抑制在急性和暴发性心肌炎治疗中的作用存在很多争议。这种疾病的发病率低，导致无法对大量病例进行研究，而且不同机构的治疗方案也存在很大差异。在这项研究中，我们介绍了在 5 例因暴发性心肌炎导致心源性休克的患者中，使用抗胸腺细胞球蛋白作为标准药物治疗的辅助手段的经验。所有病例均伴有血流动力学和电生理异常的迅速和显著改善，使患者在出院时心功能恢复到 NYHA Ⅰ级或接近正常。
