内源性神经递质激活胚胎皮质中正在分化的神经元上的N-甲基-D-天冬氨酸受体。
Endogenous neurotransmitter activates N-methyl-D-aspartate receptors on differentiating neurons in embryonic cortex.
作者信息
Blanton M G, Lo Turco J J, Kriegstein A R
机构信息
Department of Neurology and Neurological Sciences, Stanford University Medical Center, CA 94305.
出版信息
Proc Natl Acad Sci U S A. 1990 Oct;87(20):8027-30. doi: 10.1073/pnas.87.20.8027.
Abstract
Before synapses form in embryonic turtle cerebral cortex, an endogenous neurotransmitter activates N-methyl-D-aspartate (NMDA) channels on neurons in the cortical plate. Throughout cortical development, these channels exhibit voltage-dependent Mg2+ blockade and are antagonized by D-2-amino-5-phosphonovaleric acid, a selective NMDA receptor antagonist. The activation in situ of these nonsynaptic NMDA channels demonstrates a potential physiological substrate for control of early neuronal differentiation.
摘要
在胚胎期海龟大脑皮层形成突触之前，一种内源性神经递质激活皮层板中神经元上的N-甲基-D-天冬氨酸（NMDA）通道。在整个皮层发育过程中，这些通道表现出电压依赖性Mg2+阻断作用，并受到选择性NMDA受体拮抗剂D-2-氨基-5-膦酸戊酸的拮抗。这些非突触性NMDA通道的原位激活证明了控制早期神经元分化的潜在生理底物。
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