Department of Orthopaedics and University of Melbourne Department of Surgery, St. Vincent's Hospital, VIC, Australia.
Trends Mol Med. 2009 Oct;15(10):461-7. doi: 10.1016/j.molmed.2009.08.003. Epub 2009 Sep 25.
Pigment epithelium-derived factor (PEDF) has roles in antiangiogenesis and antitumourigenesis that are intimately entwined and is showing promise as a potential anticancer agent. However, the function of PEDF in the deregulated apoptotic pathways of malignant cells must first be fully characterized. Here, we review the currently known apoptotic pathways that are relevant to PEDF and cancer. Recently, a pathway that includes the PEDF receptor, PPARgamma and p53 has emerged. It is hoped that further characterization of this and other pathways involved in cancer will bring to light potential new therapeutic targets and approaches, which due to their specificity might be free of the morbidity associated with conventional chemotherapy.
色素上皮衍生因子（PEDF）在抗血管生成和抗肿瘤发生方面发挥作用，这两者紧密交织，并显示出作为潜在抗癌剂的潜力。然而，PEDF 在恶性细胞失调的凋亡途径中的功能必须首先得到充分表征。在这里，我们回顾了与 PEDF 和癌症相关的目前已知的凋亡途径。最近，出现了一个包括 PEDF 受体、PPARγ 和 p53 的途径。希望对这个途径和其他涉及癌症的途径的进一步表征将揭示潜在的新的治疗靶点和方法，由于其特异性，它们可能没有传统化疗相关的发病率。
