Department of Applied Chemistry and Pharmacy, Beijing Institute of Technology, Beijing 100081, China.
Carbohydr Res. 2009 Nov 23;344(17):2342-8. doi: 10.1016/j.carres.2009.08.035. Epub 2009 Sep 2.
The transformation of acetonides into acetates is frequently required in synthetic chemistry. An efficient procedure for direct conversion of acetonides into acetates in the presence of HClO(4)-SiO(2) under mild conditions was developed. The acetonides of primary hydroxy groups are directly converted to diacetates, and the anomeric acetonides of furanosides are stereoselectively transformed into the corresponding acetyl beta-d-furanosides with a 2-acetoxyisopropyl group.
在合成化学中，将缩酮转化为乙酸酯是经常需要的。在温和条件下，使用 HClO(4)-SiO(2)，开发出了将缩酮直接转化为乙酸酯的有效方法。伯羟基缩酮可直接转化为二乙酸酯，呋喃糖苷的端基缩酮可立体选择性地转化为相应的 2-乙酰氧基异丙基-β-D-呋喃糖苷。
