不动杆菌属中的抗生素耐药决定因子及其对大型军医院患者的临床结局影响。
Antibiotic resistance determinants in Acinetobacter spp and clinical outcomes in patients from a major military treatment facility.
机构信息
Division of Infectious Diseases and HIV Medicine, University Hospitals Case Medical Center, Cleveland, OH, USA.
出版信息
Am J Infect Control. 2010 Feb;38(1):63-5. doi: 10.1016/j.ajic.2009.05.007. Epub 2009 Sep 24.
Abstract
We explored the association of antibiotic-resistant phenotypes and genotypes in Acinetobacter spp with clinical outcomes and characteristics in 75 patients from a major military treatment facility. Amikacin resistance was associated with nosocomial acquisition of A baumannii, and carbapenem resistance and bla(OXA-23) were associated with the need for mechanical ventilation. The presence of bla(OXA-23) also correlated with longer hospital and ICU stay. Associations between bla(OXA-23) and complexity, duration, and changes made to antibiotic regimens also existed.
摘要
我们研究了 75 名来自一家大型军事治疗机构的不动杆菌属患者的抗生素耐药表型和基因型与临床结果和特征的关联。阿米卡星耐药与鲍曼不动杆菌的医院获得性感染有关，碳青霉烯类耐药和 bla(OXA-23)与需要机械通气有关。bla(OXA-23)的存在也与住院时间和 ICU 停留时间延长相关。bla(OXA-23)与复杂性、持续时间和抗生素方案的改变之间也存在关联。
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