Pesch Marina, Hülskamp Martin
University of Cologne, Botanical Institute, Gyrhofstr. 15, 50931 Cologne, Germany.
Curr Opin Plant Biol. 2009 Oct;12(5):587-92. doi: 10.1016/j.pbi.2009.07.015. Epub 2009 Sep 23.
Trichome patterning in Arabidopsis rosette leaves serves as a model system to study how individual cells are determined in a regular spacing pattern from initially equivalent cells. A conserved gene cassette regulates this spacing pattern. bHLH, MYB, and WD40 factors are positive regulators of trichome development that are inhibited by R3 single-repeat MYB proteins. One positive regulator, the WD40-protein, and the negative regulators are mobile and are transported in opposite directions: the WD40 factor moves to the negative regulators away from trichome initials. This movement behavior and the genetic and molecular interactions between the contributing genes and proteins make it very difficult to derive the mechanistic core behind pattern formation. Attempts to develop mathematical models toward this end are critically discussed.
拟南芥莲座叶上的表皮毛形态模式是研究单个细胞如何从最初等同的细胞以规则间隔模式确定的模型系统。一个保守的基因盒调节这种间隔模式。bHLH、MYB和WD40因子是表皮毛发育的正调控因子，它们受到R3单重复MYB蛋白的抑制。一种正调控因子、WD40蛋白和负调控因子是可移动的，并且沿相反方向运输：WD40因子从表皮毛起始细胞移向负调控因子。这种移动行为以及相关基因和蛋白质之间的遗传和分子相互作用使得很难推导出模式形成背后的机制核心。为此开发数学模型的尝试受到了批判性讨论。
