嘧啶并苯二氮䓬类。哌仑西平类似物的合成。
Pyrimidobenzodiazepines. Synthesis of pirenzepine analog.
作者信息
Długosz A, Machoń Z
机构信息
Department of Organic Chemistry, Medical University, Faculty of Pharmacy, Wrocław, Poland.
出版信息
Pharmazie. 1990 Jul;45(7):491-2.
PMID:1978354
Abstract
The synthesis of Pyrimido[4,5-b][1,5]benzodiazepine derivatives from 4-(o-aminophenylene)amino-5-ethoxy-carbonyl-1,2-dihydro-6-methyl-2 - oxopyrimidine has been described. Pyrimidobenzodiazepine 5 alkylated with N-methyl-N'-chloroacetyl-piperazine gives a product related to pirenzepine. Compound 5 shows weak antianxiety and antidepressive action.
摘要
已描述了由4-(邻亚苯基)氨基-5-乙氧羰基-1,2-二氢-6-甲基-2-氧代嘧啶合成嘧啶并[4,5-b][1,5]苯二氮䓬衍生物。嘧啶并苯二氮䓬5与N-甲基-N'-氯乙酰基哌嗪烷基化得到与哌仑西平相关的产物。化合物5显示出微弱的抗焦虑和抗抑郁作用。
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