Zurn A, Schmied E, Saurat J H
Clinique de dermatologie, Hôpital cantonal universitaire, Genève.
Schweiz Rundsch Med Prax. 1990 Oct 16;79(42):1254-7.
Two entities can precede the clinical and biological signs of hepatitis B virus (HBV) infection: the various lesions of the serum sickness-like prodrome (urticaria, maculopapular exanthem, purpura, etc.) induced by the deposition of intravascular circulating immune complexes and papular acrodermatitis of childhood in which the physiopathological role of HBV has not yet been established. The persistence of HBs antigen (HBs Ag) may give rise to the purpuric lesions of essential mixed cryoglobulinemia and to the livedo, the nodules and ulcerations of poly-arteritis nodosa.
在乙型肝炎病毒（HBV）感染的临床和生物学体征出现之前，可能有两种情况：一是血清病样前驱症状的各种病变（荨麻疹、斑丘疹、紫癜等），由血管内循环免疫复合物沉积所致；二是儿童丘疹性肢端皮炎，其发病机制中HBV的作用尚未明确。HBs抗原（HBs Ag）持续存在可能导致原发性混合性冷球蛋白血症的紫癜性病变以及结节性多动脉炎中的青斑、结节和溃疡。
