肥胖相关健康风险的非线性光学成像：综述
Non-Linear Optical Imaging of Obesity-Related Health Risks: Review.
作者信息
Le Thuc T, Cheng Ji-Xin
机构信息
Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, USA,
出版信息
J Innov Opt Health Sci. 2009 Jan 1;2(1):9-25. doi: 10.1142/S1793545809000371.
Abstract
This review highlights the recent applications of non-linear optical (NLO) microscopy to study obesity-related health risks. A strong emphasis is given to the applications of coherent anti-Stokes Raman scattering (CARS) microscopy where multiple non-linear optical imaging modalities including CARS, sum-frequency generation (SFG), and two-photon fluorescence are employed simultaneously on a single microscope platform. Specific examples on applications of NLO microscopy to study lipid-droplet biology, obesity-cancer relationship, atherosclerosis, and lipid-rich biological structures are discussed.
摘要
本综述重点介绍了非线性光学（NLO）显微镜在研究肥胖相关健康风险方面的最新应用。其中着重强调了相干反斯托克斯拉曼散射（CARS）显微镜的应用，即在单个显微镜平台上同时采用包括CARS、和频产生（SFG）以及双光子荧光在内的多种非线性光学成像模式。文中还讨论了NLO显微镜在研究脂滴生物学、肥胖与癌症的关系、动脉粥样硬化以及富含脂质的生物结构等方面应用的具体实例。
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