Chirkov Iu Iu, Tyshchuk I A, Severina I S
Vopr Med Khim. 1990 Jul-Aug;36(4):57-60.
Guanylate cyclase from thrombocytes with elevated ability to aggregation (diabetes mellitus) exhibited a decreased rate of activity and low response to stimulation by sodium nitroprusside and protoporphirin IX. The phenomenon observed did not depend on hem-deficiency of guanylate cyclase and was manifested most distinctly in the II type of diabetes mellitus as compared with the I type of the disease. Experimental data as well as the previously obtained results about more elevated rate of thrombocytes aggregation in patients with the II type of diabetes mellitus demonstrated that regulating functions of the cGMP system in the cells aggregation were impaired and that aggregation of thrombocytes appears to depend on the guanylate cyclase activity.
来自聚集能力增强（糖尿病）的血小板的鸟苷酸环化酶表现出活性降低以及对硝普钠和原卟啉IX刺激的低反应性。观察到的现象不依赖于鸟苷酸环化酶的血红素缺乏，并且与I型糖尿病相比，在II型糖尿病中表现得最为明显。实验数据以及先前获得的关于II型糖尿病患者血小板聚集率更高的结果表明，细胞聚集中cGMP系统的调节功能受损，并且血小板聚集似乎依赖于鸟苷酸环化酶活性。
