沙特阿拉伯卡西姆地区白癜风的遗传流行病学与遗传度

Genetic epidemiology and heritability of vitiligo in the Qassim region of Saudi Arabia.

作者信息

Alzolibani Abdullateef

机构信息

Department of Dermatology, College of Medicine, Qassim University, Saudi Arabia, PO Box 30109, Buraidah 51477, Qassim, Saudi Arabia.

出版信息

Acta Dermatovenerol Alp Pannonica Adriat. 2009 Sep;18(3):119-25.

PMID:19784525

Abstract

AIM

Assessment of consanguinity and inheritance patterns in relation to clinical subtypes of vitiligo among Saudi cases in the Qassim region based on a vitiligo case series during 2008 taken from the Qassim University-affiliated referral center.

METHODS

This study included 111 randomly selected Saudi probands affected by vitiligo and their families. They included 61 males and 50 females. Their mean age of onset was 19.13 +/- 11.97 years. Data were collected using a questionnaire administered by professional dermatologists emphasizing the clinical features as well as consanguinity and segregation pattern. Genetic analyses for inbreeding coefficient, mode of inheritance, and heritability were statistically analyzed.

RESULTS

Out of 111 probands, the frequencies of focal, vulgaris, universal, and acrofacial subtypes were 32.4%, 31.5%, 9.9%, and 26.1%, respectively. Parental consanguinity was positive in 32.4% of cases and first-cousin consanguinity in 22.5% with an inbreeding coefficient of 0.015. The family history was positive in 56.8% of cases. The mean age of onset was 19.13 +/- 11.97 years with a median of 17 years. The median age of onset was lower for consanguineous cases and cases with a positive family history. Inheritance patterns coincided more with the multifactorial model, especially for the vulgaris subtype followed by the acrofacial subtype, and coincided least with the focal subtype. Heritability or the genetic contribution to the disease showed a high weighted mean of 0.54.

CONCLUSION

Genetic factors contribute to the evolution of vitiligo among Saudi families. Discouraging consanguineous marriage is a potential prevention measure. Genetic factors contribute to the evolution of vitiligo among tribal areas of the Saudi community probably through the high consanguinity rate. In that respect, family counseling can be attempted that would discourage consanguinity and combat probable interactive environmental and health factors.

摘要

目的

基于2008年从卡西姆大学附属转诊中心获取的白癜风病例系列，评估卡西姆地区沙特病例中白癜风临床亚型与近亲结婚及遗传模式之间的关系。

方法

本研究纳入了111名随机选取的患白癜风的沙特先证者及其家族成员。其中男性61名，女性50名。他们发病的平均年龄为19.13±11.97岁。数据通过专业皮肤科医生发放的问卷收集，问卷着重关注临床特征以及近亲结婚和遗传分离模式。对近亲系数、遗传模式和遗传度进行了统计分析。

结果

在111名先证者中，局限性、寻常型、泛发型和肢端颜面型亚型的频率分别为32.4%、31.5%、9.9%和26.1%。32.4%的病例存在父母近亲结婚情况，22.5%的病例存在表亲近亲结婚情况，近亲系数为0.015。56.8%的病例有家族病史。发病的平均年龄为19.13±11.97岁，中位数为17岁。近亲结婚病例和有家族病史的病例发病年龄中位数较低。遗传模式与多因素模型更为相符，尤其是寻常型亚型，其次是肢端颜面型亚型，与局限性亚型最不相符。遗传度或疾病的遗传贡献显示加权平均值较高，为0.54。