Alenizi Dhaifallah A
Department of Dermatology, College of Medicine, Northern Borders University, Arar, Kingdom of Saudi Arabia.
J Family Community Med. 2014 Jan;21(1):13-6. doi: 10.4103/2230-8229.128767.
Epidemiological studies have shown that vitiligo is a complex trait, involving combinations of pathogenic effects of multiple susceptibility genes as well as environmental risk factors.
To observe whether consanguinity increased the incidence of vitiligo in Saudi patients from Arar.
This study included 69 Saudi patients with vitiligo and their families. These patients, selected from the experience specialist dermatology center in Arar, from April 2011 to 2012, were interviewed by a dermatologist to confirm the diagnosis and complete a questionnaire.
A total of 69 patients, 40 males and 29 females were selected. Their mean age was 34.5 ± 11.8 years with the median age of 23 years. The mean age at onset of disease was 27.9 ± 12.9 years. The mean duration of the disease was 9.7 ± 5.3 years. The frequency of focal, vulgaris, universal, and acrofacial subtypes was 22 (31.9%), 21 (30.4%), 8 (11.6%), and 18 (26.1%), respectively. A positive family history of vitiligo was obtained in 45 (65.2%) cases. A comparison of the frequency of vitiligo among siblings in relation to the general population was more in accord with the multifactorial model.
Consanguinity in marriage increases the incidence of the disease. Therefore, genetic counseling and premarital examination would be important contributions to lower the prevalence of vitiligo.
流行病学研究表明，白癜风是一种复杂的性状，涉及多个易感基因的致病作用以及环境风险因素的综合影响。
观察近亲结婚是否会增加来自阿赖尔的沙特患者患白癜风的发病率。
本研究纳入了69例沙特白癜风患者及其家属。这些患者于2011年4月至2012年从阿赖尔经验丰富的专科皮肤科中心选取，由皮肤科医生进行访谈以确诊并完成一份问卷。
共选取了69例患者，其中男性40例，女性29例。他们的平均年龄为34.5±11.8岁，中位年龄为23岁。疾病发病的平均年龄为27.9±12.9岁。疾病的平均病程为9.7±5.3年。局限性、寻常型、泛发型和肢端颜面型亚型的频率分别为22例（31.9%）、21例（30.4%）、8例（11.6%）和18例（26.1%）。45例（65.2%）患者有白癜风家族史阳性。与一般人群相比，兄弟姐妹中白癜风的发病频率更符合多因素模型。
近亲结婚会增加该疾病的发病率。因此，遗传咨询和婚前检查对于降低白癜风的患病率将有重要作用。
