哈曼当归化学成分的生物活性。

Biological activity of chemical constituents from Clausena harmandiana.

机构信息

Center for Innovation in Chemistry, Department of Chemistry, Khon Kaen University, Thailand.

出版信息

Arch Pharm Res. 2010 May;33(5):675-80. doi: 10.1007/s12272-010-0505-x. Epub 2010 May 29.

PMID:20512464

Abstract

The activity guided fractionation of the Clausena harmandiana root extracts led to the isolation of a coumarin, a ferulate, and eight carbazoles. This is the first report of the isolation of compounds 2-4 and 6-10 from this species, and this is the first time 10 was isolated from this genus. Compound 4 showed strong cytotoxicity against NCI-H187 cells with an IC(50) value of 1.63 microg/mL. Compound 5 demonstrated strong cytotoxicity against MCF-7 and KB cell lines with IC50 values of 2.21 and 1.74 microg/mL, respectively. Compounds 3 and 4 exhibited moderate cytotoxicity against the MCF-7 cell line, and 8 showed moderate cytotoxicity against NCIH187 and KB cell lines. Compounds 3 and 5 showed antiplasmodial activity with IC(50) values of 3.27 and 2.94 microg/mL, respectively.

摘要

从胡桐（Clausena harmandiana）根提取物的活性导向分离中，得到了一个香豆素、一个阿魏酸和八个咔唑类化合物。这是首次从该物种中分离出化合物 2-4 和 6-10，也是首次从该属中分离出化合物 10。化合物 4 对 NCI-H187 细胞表现出强烈的细胞毒性，IC50 值为 1.63 µg/mL。化合物 5 对 MCF-7 和 KB 细胞系表现出强烈的细胞毒性，IC50 值分别为 2.21 和 1.74 µg/mL。化合物 3 和 4 对 MCF-7 细胞系表现出中等的细胞毒性，化合物 8 对 NCI-H187 和 KB 细胞系表现出中等的细胞毒性。化合物 3 和 5 对疟原虫表现出抗疟原虫活性，IC50 值分别为 3.27 和 2.94 µg/mL。